1 March 2016
Penarol – Huracan
Referee: Cesar Ramos (MEX, photo)
Assistant Referee 1: Marcos Quintero (MEX)
Assistant Referee 2: Miguel Hernandez (MEX)
Fourth Official: Luis Santander (MEX)
Referee Observer: Jorge Larrionda (URU)
Melgar – Independiente del Valle
Referee: Oscar Rojas (URU)
Assistant Referee 1: Nicolas Taran (URU)
Assistant Referee 2: Horacio Ferreiro (URU)
Fourth Official: Esteban Ostojich (URU)
Referee Observer: Antonio Arnao (PER)
Olimpia – Pumas Unam
Referee: German Delfino (ARG)
Assistant Referee 1: Hernan Maidana (ARG)
Assistant Referee 2: Diego Bonfa (ARG)
Fourth Official: Diego Abal (ARG)
Referee Observer: Manuel Bernal (PAR)
Atlético Nacional – Sporting Cristal
Referee: Óscar Maldonado (BOL)
Assistant Referee 1: Javier Bustillos (BOL)
Assistant Referee 2: José Antelo (BOL)
Fourth Official: José Jordán (BOL)
Referee Observer: Dember Perdomo (COL)
2 March 2016
The Strongest – Trujillanos
Referee: Gustavo Murillo (COL)
Assistant Referee 1: Alexander Guzman (COL)
Assistant Referee 2: Dionisio Ruiz (COL)
Fourth Official: Luis Sanchez (COL)
Referee Observer: Marcelo Ortube (BOL)
Nacional – River
Referee: Victor Carrillo (PER)
Assistant Referee 1: Jonny Bossio (PER)
Assistant Referee 2: Raul Lopez (PER)
Fourth Official: Michael Espinoza (PER)
Referee Observer: Juan Cardellino (URU)
San Lorenzo – Toluca
Referee: Enrique Osses (CHI)
Assistant Referee 1: Carlos Astroza (CHI)
Assistant Referee 2: Christian Schiemann (CHI)
Fourth Official: Claudio Puga (CHI)
Referee Observer: Carlos Coradina (ARG)
Gremio – Liga de Quito
Referee: Jesus Valenzuela (VEN)
Assistant Referee 1: Carlos Lopez (VEN)
Assistant Referee 2: Luis Sanchez (VEN)
Fourth Official: Marlon Escalante (VEN)
Referee Observer: Jose Mocellin (BRA)
Corinthians – Santa Fe
Referee: Mauro Vigliano (ARG)
Assistant Referee 1: Juan Belatti (ARG)
Assistant Referee 2: Cristian Navarro (ARG)
Fourth Official: Silvio Trucco (ARG)
Referee Observer: Nilson Moncao (BRA)
3 March 2016
Boca Juniors – Racing
Referee: Sandro Ricci (BRA)
Assistant Referee 1: Emerson Carvalho (BRA)
Assistant Referee 2: Rodrigo Correa (BRA)
Fourth Official: Dewson Freitas (BRA)
Referee Observer: Luis Bongianino (ARG)
Palmeiras – Rosario Central
Referee: Enrique Caceres (PAR)
Assistant Referee 1: Carlos Caceres (PAR)
Assistant Referee 2: Milciades Saldivar (PAR)
Fourth Official: Ulises Mereles (PAR)
Referee Observer: Ednilson Corona (BRA)
Bolívar – Deportivo Cali
Referee: Carlos Orbe (ECU)
Assistant Referee 1: Byron Romero (ECU)
Assistant Referee 2: Luis Vera (ECU)
Fourth Official: Vinicio Espinel (ECU)
Referee Observer: Oscar Ortube (BOL)