Qabala IK – Hajduk Split
Referee: Arda Kardeşler (TUR, photo)
Assistant Referee 1: Mehmet Tugral (TUR)
Assistant Referee 2: Süleyman Özay (TUR)
Fourth Official: Kamal Umudlu (AZE)
Referee Observer: Asim Xudiyev (AZE)
Shamrock Rovers – AZ Alkmaar
Referee: Urs Schnyder (SUI)
Assistant Referee 1: Jonas Erni (SUI)
Assistant Referee 2: Benjamin Zürcher (SUI)
Referee Observer: David Malcolm (NIR)
5 October 2022
FS Jelgava – MTK Budapest
Referee: Georgi Davidov (BUL)
Assistant Referee 1: Deniz Sokolov (BUL)
Assistant Referee 2: Miroslav Ivanov (BUL)
Fourth Official: Aleksandrs Anufrijevs (LVA)
Referee Observer: Nerijus Dunauskas (LTU)
Slavia Praha – KRC Genk
Referee: Luka Bilbija (BIH)
Assistant Referee 1: Stefan Tešanović (BIH)
Assistant Referee 2: Moamer Čaušević (BIH)
Fourth Official: Marek Radina (CZE)
Referee Observer: Vladimir Medved (SVK)
Pobeda Prilep – Coleraine FC
Referee: Sven Jablonski (GER)
Assistant Referee 1: Christof Günsch (GER)
Assistant Referee 2: Eric Müller (GER)
Fourth Official: Marjan Dejanoski (MKD)
Referee Observer: Dimitar Mečkarovski (MKD)
KF Apolonia – Astana FK
Referee: Amine Kourgheli (BLR)
Assistant Referee 1: Juryj Chomčanka (BLR)
Assistant Referee 2: Viktar Hiecikaŭ (BLR)
Fourth Official: Kreshnik Cjapi (ALB)
Referee Observer: Albano Janku (ALB)
Galatasaray – AFK Csikszereda
Referee: Robert Hennessy (IRL)
Assistant Referee 1: Dermot Broughton (IRL)
Assistant Referee 2: Emmett Dynan (IRL)
Fourth Official: Can Cengiz (TUR)
Referee Observer: Bariş Şimşek (TUR)
Omonia Lefkosias – Crvena Zvezda
Referee: Ishmael Barbara (MLT)
Assistant Referee 1: Duncan Sultana (MLT)
Assistant Referee 2: Duncan Spencer (MLT)
Fourth Official: Ioannis Christodoulou (CYP)
Referee Observer: Christos Nikolaidis (CYP)
Pyunik FA – FC Nantes
Referee: Michal Očenaš (SVK)
Assistant Referee 1: Tomaš Vorel (SVK)
Assistant Referee 2: Dušan Štofik (SVK)
Fourth Official: Artem Gasparyan (ARM)
Referee Observer: Vencel Tóth (HUN)
Slavia Sofia – Panathinaikos
Referee: Alessandro Dudic (SUI)
Assistant Referee 1: Alain Heiniger (SUI)
Assistant Referee 2: Jan Köbeli (SUI)
Fourth Official: Ivo Andreev (BUL)
Referee Observer: Kostadin Gerginov (BUL)
NK Domžale – BSC Young Boys
Referee: Miloš Savović (MNE)
Assistant Referee 1: Aleksandar Djikanović (MNE)
Assistant Referee 2: Ivan Bogdanović (MNE)
Fourth Official: Denis Šabanagić (SVN)
Referee Observer: Ante Vučemilović-Šimunović (CRO)
AS Trencin – Zalgiris Vilnius
Referee: Andrei Chivulete (ROU)
Assistant Referee 1: Mihai Marica (ROU)
Assistant Referee 2: Ferencz Tunyogy (ROU)
Fourth Official: Martin Dohal (SVK)
Referee Observer: Michal Beneš (CZE)
Zaglebie Lubin – Rukh Lviv
Referee: Ashot Ghaltakhchyan (ARM)
Assistant Referee 1: Sargis Hovhannisyan (ARM)
Assistant Referee 2: Gevorg Shakhkaldyan (ARM)
Fourth Official: Sebastian Tarnowski (POL)
Referee Observer: Robert Malek (POL)
Union Lëtzebuerg – AIK
Referee: Jan Machalek (CZE)
Assistant Referee 1: Marek Podany (CZE)
Assistant Referee 2: Jan Hurych (CZE)
Fourth Official: Jeremy Muller (LUX)
Referee Observer: Guy Goethals (BEL)
Hibernian – Molde
Referee: Helgi Jonasson (ISL)
Assistant Referee 1: Kristjan Olafs (ISL)
Assistant Referee 2: Eysteinn Hrafnkelsson (ISL)
Fourth Official: Peter Stuart (SCO)
Referee Observer: Jens Larsen (DEN)
12 October 2022
Borac Banja Luka – Ashdod FC
Referee: David Munro (SCO)
Assistant Referee 1: Ross McLeod (SCO)
Assistant Referee 2: Sean Carr (SCO)
Fourth Official: Miloš Gigović (BIH)
Referee Observer: Draženko Kovačić (CRO)
Referee: Arda Kardeşler (TUR, photo)
Assistant Referee 1: Mehmet Tugral (TUR)
Assistant Referee 2: Süleyman Özay (TUR)
Fourth Official: Kamal Umudlu (AZE)
Referee Observer: Asim Xudiyev (AZE)
Shamrock Rovers – AZ Alkmaar
Referee: Urs Schnyder (SUI)
Assistant Referee 1: Jonas Erni (SUI)
Assistant Referee 2: Benjamin Zürcher (SUI)
Referee Observer: David Malcolm (NIR)
5 October 2022
FS Jelgava – MTK Budapest
Referee: Georgi Davidov (BUL)
Assistant Referee 1: Deniz Sokolov (BUL)
Assistant Referee 2: Miroslav Ivanov (BUL)
Fourth Official: Aleksandrs Anufrijevs (LVA)
Referee Observer: Nerijus Dunauskas (LTU)
Slavia Praha – KRC Genk
Referee: Luka Bilbija (BIH)
Assistant Referee 1: Stefan Tešanović (BIH)
Assistant Referee 2: Moamer Čaušević (BIH)
Fourth Official: Marek Radina (CZE)
Referee Observer: Vladimir Medved (SVK)
Pobeda Prilep – Coleraine FC
Referee: Sven Jablonski (GER)
Assistant Referee 1: Christof Günsch (GER)
Assistant Referee 2: Eric Müller (GER)
Fourth Official: Marjan Dejanoski (MKD)
Referee Observer: Dimitar Mečkarovski (MKD)
KF Apolonia – Astana FK
Referee: Amine Kourgheli (BLR)
Assistant Referee 1: Juryj Chomčanka (BLR)
Assistant Referee 2: Viktar Hiecikaŭ (BLR)
Fourth Official: Kreshnik Cjapi (ALB)
Referee Observer: Albano Janku (ALB)
Galatasaray – AFK Csikszereda
Referee: Robert Hennessy (IRL)
Assistant Referee 1: Dermot Broughton (IRL)
Assistant Referee 2: Emmett Dynan (IRL)
Fourth Official: Can Cengiz (TUR)
Referee Observer: Bariş Şimşek (TUR)
Omonia Lefkosias – Crvena Zvezda
Referee: Ishmael Barbara (MLT)
Assistant Referee 1: Duncan Sultana (MLT)
Assistant Referee 2: Duncan Spencer (MLT)
Fourth Official: Ioannis Christodoulou (CYP)
Referee Observer: Christos Nikolaidis (CYP)
Pyunik FA – FC Nantes
Referee: Michal Očenaš (SVK)
Assistant Referee 1: Tomaš Vorel (SVK)
Assistant Referee 2: Dušan Štofik (SVK)
Fourth Official: Artem Gasparyan (ARM)
Referee Observer: Vencel Tóth (HUN)
Slavia Sofia – Panathinaikos
Referee: Alessandro Dudic (SUI)
Assistant Referee 1: Alain Heiniger (SUI)
Assistant Referee 2: Jan Köbeli (SUI)
Fourth Official: Ivo Andreev (BUL)
Referee Observer: Kostadin Gerginov (BUL)
NK Domžale – BSC Young Boys
Referee: Miloš Savović (MNE)
Assistant Referee 1: Aleksandar Djikanović (MNE)
Assistant Referee 2: Ivan Bogdanović (MNE)
Fourth Official: Denis Šabanagić (SVN)
Referee Observer: Ante Vučemilović-Šimunović (CRO)
AS Trencin – Zalgiris Vilnius
Referee: Andrei Chivulete (ROU)
Assistant Referee 1: Mihai Marica (ROU)
Assistant Referee 2: Ferencz Tunyogy (ROU)
Fourth Official: Martin Dohal (SVK)
Referee Observer: Michal Beneš (CZE)
Zaglebie Lubin – Rukh Lviv
Referee: Ashot Ghaltakhchyan (ARM)
Assistant Referee 1: Sargis Hovhannisyan (ARM)
Assistant Referee 2: Gevorg Shakhkaldyan (ARM)
Fourth Official: Sebastian Tarnowski (POL)
Referee Observer: Robert Malek (POL)
Union Lëtzebuerg – AIK
Referee: Jan Machalek (CZE)
Assistant Referee 1: Marek Podany (CZE)
Assistant Referee 2: Jan Hurych (CZE)
Fourth Official: Jeremy Muller (LUX)
Referee Observer: Guy Goethals (BEL)
Hibernian – Molde
Referee: Helgi Jonasson (ISL)
Assistant Referee 1: Kristjan Olafs (ISL)
Assistant Referee 2: Eysteinn Hrafnkelsson (ISL)
Fourth Official: Peter Stuart (SCO)
Referee Observer: Jens Larsen (DEN)
12 October 2022
Borac Banja Luka – Ashdod FC
Referee: David Munro (SCO)
Assistant Referee 1: Ross McLeod (SCO)
Assistant Referee 2: Sean Carr (SCO)
Fourth Official: Miloš Gigović (BIH)
Referee Observer: Draženko Kovačić (CRO)