UEFA Champions League 2021/2022 – Round of 16 (First Leg, II)

22 February 2022

Villarreal CF – Juventus
Referee: Daniel Siebert (GER, photo)
Assistant Referee 1: Jan Seidel (GER)
Assistant Referee 2: Rafael Foltyn (GER)
Fourth Official: Sven Jablonski (GER)
VAR: Bastian Dankert (GER)
AVAR: Harm Osmers (GER)
Referee Observer: Rune Pedersen (NOR)

Chelsea FC – LOSC Lille
Referee: Jesus Gil Manzano (ESP)
Assistant Referee 1: Inigo Prieto Lopez (ESP)
Assistant Referee 2: Angel Nevado Rodriguez (ESP)
Fourth Official: Jose Munuera Montero (ESP)
VAR: Alejandro Hernandez Hernandez (ESP)
AVAR: Ricardo De Burgos Bengoetxea (ESP)
Referee Observer: Roberto Rosetti (ITA)

23 February 2022
SL Benfica – AFC Ajax
Referee: Slavko Vinčić (SVN)
Assistant Referee 1: Tomaž Klančnik (SVN)
Assistant Referee 2: Andraž Kovačič (SVN)
Fourth Official: Rade Obrenovič (SVN)
VAR: Marco Fritz (GER)
AVAR: Jure Praprotnik (SVN)
Referee Observer: Pascal Garibian (FRA)

Atletico de Madrid – Manchester United
Referee: Ovidiu Hategan (ROU)
Assistant Referee 1: Mircea Grigoriu (ROU)
Assistant Referee 2: Sebastian Gheorghe (ROU)
Fourth Official: Radu Petrescu (ROU)
VAR: Massimiliano Irrati (ITA)
AVAR: Marco Guida (ITA)
Referee Observer: Francesco Bianchi (SUI)