Concacaf League 2021 – Round of 16 (Second Leg)

28-30 September 2021

Independiente – Forge FC
Referee: Keylor Herrera (CRC, photo)
Assistant Referee 1: Carlos Fernandez (CRC)
Assistant Referee 2: William Chow (CRC)
Fourth Official: Benjamin Pineda (CRC)

Alajuelense – Guastatoya
Referee: Adonai Escobedo (MEX)
Assistant Referee 1: Michel Morales (MEX)
Assistant Referee 2: Karen Diaz (MEX)
Fourth Official: German Martinez (SLV)

Alianza – Comunicaciones
Referee: Pierre-Luc Lauziere (CAN)
Assistant Referee 1: Chris Wattam (CAN)
Assistant Referee 2: Lyes Arfa (CAN)
Fourth Official: Kevin Morrison (JAM)

Real Esteli – CD Marathon
Referee: Oscar Macias (MEX)
Assistant Referee 1: Christian Espinoza (MEX)
Assistant Referee 2: Andres Hernandez (MEX)
Fourth Official: Jaime Herrera (SLV)

Plaza Amador – Santos de Guapiles
Referee: Oscar Reyna (GUA)
Assistant Referee 1: Luis Ventura (GUA)
Assistant Referee 2: Rene Ochoa (GUA)
Fourth Official: Bryan Lopez (GUA)

Deportivo Saprissa – Santa Lucia
Referee: Rubiel Vazquez (USA)
Assistant Referee 1: Logan Brown (USA)
Assistant Referee 2: Felisha Mariscal (USA)
Fourth Official: Ekaterina Koroleva (USA)

Motagua – Universitario
Referee: Oscar Mejia (MEX)
Assistant Referee 1: Jose Martinez (MEX)
Assistant Referee 2: Enedina Caudillo (MEX)
Fourth Official: Marco Ortiz (MEX)