Concacaf Champions League 2021 – Round of 16 (First Leg)

6-8 April 2021

CD Marathon – Portland Timbers
Referee: Cesar Ramos (MEX, photo)
Assistant Referee 1: Alberto Morin (MEX)
Assistant Referee 2: Jesus Tabora (HON)
Fourth Official: Oscar Macias (MEX)

LD Alajuelense – Atlanta United
Referee: Said Martinez (HON)
Assistant Referee 1: Walter Lopez (HON)
Assistant Referee 2: Roney Salinas (HON)
Fourth Official: Tristley Bassue (SKN)

Arcahaie FC – Cruz Azul
Referee: Kimbell Ward (SKN)
Assistant Referee 1: Graeme Browne (SKN)
Assistant Referee 2: Ike Inniss (GUY)
Fourth Official: Trevester Richards (SKN)

Deportivo Saprissa – Philadelphia Union
Referee: Ismael Cornejo (SLV)
Assistant Referee 1: David Moran (SLV)
Assistant Referee 2: Geovany Garcia (SLV)
Fourth Official: Ivan Barton (SLV)

Club Leon – Toronto FC
Referee: Ricardo Montero (CRC)
Assistant Referee 1: William Arrieta (CRC)
Assistant Referee 2: Juan Mora (CRC)
Fourth Official: Keylor Herrera (CRC)

CD Olimpia – Club America
Referee: Ismail Elfath (USA)
Assistant Referee 1: Corey Parker (USA)
Assistant Referee 2: Kyle Atkins (USA)
Fourth Official: Nima Saghafi (USA)

Real Esteli – Columbus Crew
Referee: Selvin Brown (HON)
Assistant Referee 1: Christian Ramirez (HON)
Assistant Referee 2: Gerson Orellana (HON)
Fourth Official: Nelson Salgado (HON)

CA Pantoja – CF Monterrey
Referee: Oshane Nation (JAM)
Assistant Referee 1: Damian Williams (JAM)
Assistant Referee 2: Jassett Kerr (JAM)
Fourth Official: Daneon Parchment (JAM)