27 October 2015
Defensor Sporting – Huracan
Referee: Roddy Zambrano (ECU, photo)
Assistant Referee 1: Christian Lescano (ECU)
Assistant Referee 2: Byron Romero (ECU)
Fourth Official: Diego Lara (ECU)
Referee Observer: Gustavo Lopez (URU)
28 October 2015
Sportivo Luqueno – Atletico Paranaense
Referee: Christian Ferreyra (URU)
Assistant Referee 1: Miguel Nievas (URU)
Assistant Referee 2: Gabriel Popovits (URU)
Fourth Official: Fernando Falce (URU)
Referee Observer: Manuel Bernal (PAR)
Chapecoense – River Plate
Referee: Julio Bascunan (CHI)
Assistant Referee 1: Raul Orellana (CHI)
Assistant Referee 2: Claudio Rios (CHI)
Fourth Official: Patricio Polic (CHI)
Referee Observer: Alicio Pena (BRA)
29 October 2015
Santa Fe – Independiente
Referee: Jose Argote (VEN)
Assistant Referee 1: Luis Sanchez (VEN)
Assistant Referee 2: Carlos Lopez (VEN)
Fourth Official: Mayker Gomez (VEN)
Referee Observer: Otalvaro Polanco (COL)