25 October 2011 Independiente Santa Fe– Botafogo
Referee: Roberto Silvera (URU, photo)
Assistant Referee 1: Pablo Fandino (URU)
Assistant Referee 2: Mauricio Espinosa (URU)
Fourth Official: Imer Machado (COL)
26 October 2011
Vasco da Gama– Aurora
Referee: Julio Quintana (PAR)
Assistant Referee 1: Rodney Aquino (PAR)
Assistant Referee 2: Dario Goana (PAR)
Fourth Official: Marcelo Henrique (BRA)
Libertad – Sao Paulo
Referee: Wilmar Roldan (COL)
Assistant Referee 1: Eduardo Diaz (COL)
Assistant Referee 2: Wilson Berrio (COL)
Fourth Official: Enrique Caceres (PAR)
Universidad de Chile – Flamengo
Referee: Carlos Amarilla (PAR)
Assistant Referee 1: Milciades Saldivar (PAR)
Assistant Referee 2: Carlos Caceres (PAR)
Fourth Official: Julio Bascunan (CHI)
