1 November 2022 Crvena Zvezda – AZ Alkmaar
Referee: David Fuxman (ISR, photo)
Assistant Referee 1: Omer Barbiro (ISR)
Assistant Referee 2: Israel Feldman (ISR)
Fourth Official: Nikola Đorđević (SRB)
Referee Observer: Clayton Pisani (MLT)
2 November 2022
FK Rukh Lviv – Galatasaray
Referee: Nenad Minaković (SRB)
Assistant Referee 1: Nikola Rijavec (SRB)
Assistant Referee 2: Marko Živković (SRB)
Fourth Official: Jacek Małyszek (POL)
Referee Observer: Robert Malek (POL)
KRC Genk – Coleraine FC
Referee: Viktar Šymusik (BLR)
Assistant Referee 1: Siarhiej Kasaviec (BLR)
Assistant Referee 2: Siarhiej Firynovič (BLR)
Fourth Official: Simon Bourdeaud’hui (BEL)
Referee Observer: Calum Murray (SCO)
Hajduk Split – KF Apolonia
Referee: Yigal Frid (ISR)
Assistant Referee 1: Matityahu Yakobov (ISR)
Assistant Referee 2: Valentyn Kuzhevski (ISR)
Fourth Official: Ante Terzić (CRO)
Referee Observer: Draženko Kovačić (CRO)
MTK Budapest – Ashdod SC
Referee: Evangelos Manouchos (GRE)
Assistant Referee 1: Konstantinos Nikolaidis (GRE)
Assistant Referee 2: Andreas Fotopoulos (GRE)
Fourth Official: Peter Zierkelbach (HUN)
Referee Observer: Vencel Toth (HUN)
AS Trenčin – Panathinaikos
Referee: Chrysovalandis Theouli (CYP)
Assistant Referee 1: Lambros Lambrou (CYP)
Assistant Referee 2: Georgios Charalambous (CYP)
Fourth Official: Balint Kiss (SVK)
Referee Observer: Ladislav Gadosi (SVK)
FC Nantes – Hibernian FC
Referee: Kari Havdanum (FRO)
Assistant Referee 1: Jorleif Djurhuus (FRO)
Assistant Referee 2: Jogvan Klakstein (FRO)
Fourth Official: Romain Lissorgue (FRA)
Referee Observer: Pascal Garibian (FRA)
AIK – Young Boys
Referee: Oleksiy Derevinskyy (UKR)
Assistant Referee 1: Dmytro Zaporozhenko (UKR)
Assistant Referee 2: Volodymyr Vysotskyy (UKR)
Fourth Official: Erik Mattsson (SWE)
Referee Observer: Stefan Johannesson (SWE)