13 March 2022
JS Saoura – Al Ittihad
Referee: Mahmoud El-Banna (EGY, photo)
Assistant Referee 1: Han Mahmoud (EGY)
Assistant Referee 2: Samy Halhal (EGY)
Fourth Official: Ahmed Ghandour (EGY)
Coton Sport – TP Mazembe
Referee: Helder Martins (ANG)
Assistant Referee 1: Jerson Dos Santos (ANG)
Assistant Referee 2: Ivanildo Meirelles (ANG)
Fourth Official: Joao Goma (ANG)
Zanaco – Al Ahli
Referee: Hassan Hagi (SOM)
Assistant Referee 1: Hamza Abdi (SOM)
Assistant Referee 2: Nour Mohamed (SOM)
Fourth Official: Omar Artan (SOM)
CS Sfaxien – Pyramids
Referee: Jean Ishimwe (RWA)
Assistant Referee 1: Dieudonne Mutuyimana (RWA)
Assistant Referee 2: Raymond Bwiliza (RWA)
Fourth Official: Louis Hakizimana (RWA)
Orlando Pirates – Royal Leopards
Referee: Athoumani Mohamed (COM)
Assistant Referee 1: Souleimane Amaldine (COM)
Assistant Referee 2: Said Chebli (COM)
Fourth Official: Soulaimane Ansudane (COM)
Al Masry – AS Otoho
Referee: Ahmad Heeralall (MRI)
Assistant Referee 1: Baje Babajee (MRI)
Assistant Referee 2: Sailesh Gobin (MRI)
Fourth Official: Patrice Milazare (MRI)
Simba – Berkane
Referee: Jean Ndala Ngambo (COD)
Assistant Referee 1: Olivier Safari (COD)
Assistant Referee 2: Leon Kikumbi (COD)
Fourth Official: Yannick Malala (COD)
Mimosas – USGN
Referee: Bernard Camille (SEY)
Assistant Referee 1: Hensley Petrousse (SEY)
Assistant Referee 2: Gerard Pool (SEY)
Fourth Official: Eldrick Adelaide (SEY)