11-12 March 2022
Al Hilal – Al Merrikh
Referee: Mustapha Ghorbal (ALG, photo)
Assistant Referee 1: Mokrane Gourari (ALG)
Assistant Referee 2: Abdelhak Etchiali (ALG)
Fourth Official: Mehdi Abid Charef (ALG)
Mamelodi Sundowns – Al Ahly
Referee: Bamlak Tessema (ETH)
Assistant Referee 1: Elvis Noupue (CMR)
Assistant Referee 2: Issa Yaya (CHA)
Fourth Official: Blaise Ngwa (CMR)
Horoya – Raja Casablanca
Referee: Boubou Traore (MLI)
Assistant Referee 1: Modibo Samake (MLI)
Assistant Referee 2: Baba Yomboliba (MLI)
Fourth Official: Ibrahima Keita (MLI)
ES Setif – AmaZulu
Referee: Haythem Guirat (TUN)
Assistant Referee 1: Mohamed Bakir (TUN)
Assistant Referee 2: Yamen Melloulchi (TUN)
Fourth Official: Mohamed Bouali (TUN)
CR Belouizdad – Jwaneng Galaxy
Referee: Sabri Fadul (SDN)
Assistant Referee 1: Mohammed Ibrahim (SDN)
Assistant Referee 2: Omer Ahmed (SDN)
Fourth Official: Mahmood Ismail (SDN)
Etoile du Sahel – Esperance de Tunis
Referee: Mohamed Maarouf (EGY)
Assistant Referee 1: Mahmoud El-Regal (EGY)
Assistant Referee 2: Ahmed El-Din (EGY)
Fourth Official: Amin Omar (EGY)
Zamalek – Wydad AC
Referee: Pacifique Ndabihawenimana (BDI)
Assistant Referee 1: Emery Niyongabo (BDI)
Assistant Referee 2: Pascal Ndimunzigo (BDI)
Fourth Official: Georges Gatogato (BDI)
Petro de Luanda – Sagrada Esperanca
Referee: Janny Sikazwe (ZAM)
Assistant Referee 1: Souru Phatsoane (LES)
Assistant Referee 2: Thomas Kaela (ZAM)
Fourth Official: Joshua Bondo (BOT)