AFC Ajax – Beşiktaş JK
Referee: Benoît Bastien (FRA, photo)
Assistant Referee 1: Hicham Zakrani (FRA)
Assistant Referee 2: Aurelien Berthomieu (FRA)
Fourth Official: Jeremie Pignard (FRA)
VAR: Willy Delajod (FRA)
AVAR: Massimiliano Irrati (ITA)
Referee Observer: Leslie Irvine (NIR)
Shakhtar Donetsk – Inter Milano
Referee: Istvan Kovacs (ROU)
Assistant Referee 1: Vasile Marinescu (ROU)
Assistant Referee 2: Ovidiu Artene (ROU)
Fourth Official: Andrei Chivulete (ROU)
VAR: Marco Fritz (GER)
AVAR: Ovidiu Hațegan (ROU)
Referee Observer: Jorn West Larsen (DEN)
Paris St. Germain – Manchester City
Referee: Carlos Del Cerro Grande (ESP)
Assistant Referee 1: Pau Cebrian Devis (ESP)
Assistant Referee 2: Roberto Alonso Fernandez (ESP)
Fourth Official: Santiago Jaime Latre (ESP)
VAR: Juan Martinez Munuera (ESP)
AVAR: Christian Dingert (GER)
Referee Observer: Markus Nobs (SUI)
RB Leipzig – Club Brugge
Referee: Slavko Vinčić (SVN)
Assistant Referee 1: Tomaž Klančnik (SVN)
Assistant Referee 2: Andraž Kovačič (SVN)
Fourth Official: Nejc Kajtazović (SVN)
VAR: Paolo Valeri (ITA)
AVAR: Maurizio Mariani (ITA)
Referee Observer: Stefan Messner (AUT)
FC Porto – Liverpool
Referee: Sergei Karasev (RUS)
Assistant Referee 1: Igor Demeshko (RUS)
Assistant Referee 2: Maksim Gavrilin (RUS)
Fourth Official: Vladimir Moskalev (RUS)
VAR: Bastian Dankert (GER)
AVAR: Vitali Meshkov (RUS)
Referee Observer: Haim Jakov (ISR)
AC Milan – Atletico de Madrid
Referee: Cüneyt Çakir (TUR)
Assistant Referee 1: Bahattin Duran (TUR)
Assistant Referee 2: Tarik Ongun (TUR)
Fourth Official: Arda Kardeşler (TUR)
VAR: Abdulkadir Bitigen (TUR)
AVAR: Mete Kalkavan (TUR)
Referee Observer: Guy Goethals (BEL)
Borussia Dortmund – Sporting Clube de Portugal
Referee: Srdjan Jovanović (SRB)
Assistant Referee 1: Uroš Stojković (SRB)
Assistant Referee 2: Milan Mihajlović (SRB)
Fourth Official: Novak Simović (SRB)
VAR: Pol van Boekel (NED)
AVAR: Kevin Blom (NED)
Referee Observer: Domenico Messina (ITA)
Real Madrid – Sheriff Tiraspol
Referee: Lawrence Visser (BEL)
Assistant Referee 1: Rien Vanyzere (BEL)
Assistant Referee 2: Thibaud Nijssen (BEL)
Fourth Official: Bram Van Driessche (BEL)
VAR: Clement Turpin (FRA)
AVAR: Amaury Delerue (FRA)
Referee Observer: Herbert Fandel (GER)
29 September 2021
Atalanta BC – BSC Young Boys
Referee: Felix Brych (GER)
Assistant Referee 1: Mark Borsch (GER)
Assistant Referee 2: Stefan Lupp (GER)
Fourth Official: Daniel Schlager (GER)
VAR: Sascha Stegemann (GER)
AVAR: Deniz Aytekin (GER)
Referee Observer: Sergey Zuev (RUS)
FC Zenit – Malmö FF
Referee: Anastasios Sidiropoulos (GRE)
Assistant Referee 1: Polychronis Kostaras (GRE)
Assistant Referee 2: Lazaros Dimitriadis (GRE)
Fourth Official: Ioannis Papadopoulos (GRE)
VAR: Jose Sanchez Martinez (ESP)
AVAR: Guillermo Cuadra Fernandez (ESP)
Referee Observer: Marian Ružbarsky (SVK)
Bayern München – Dynamo Kyiv
Referee: Marco Guida (ITA)
Assistant Referee 1: Filippo Meli (ITA)
Assistant Referee 2: Giorgio Peretti (ITA)
Fourth Official: Fabio Maresca (ITA)
VAR: Maurizio Mariani (ITA)
AVAR: Paolo Valeri (ITA)
Referee Observer: Juan Fernandez Marin
SL Benfica – FC Barcelona
Referee: Daniele Orsato (ITA)
Assistant Referee 1: Alessandro Giallatini (ITA)
Assistant Referee 2: Ciro Carbone (ITA)
Fourth Official: Daniele Doveri (ITA)
VAR: Massimiliano Irrati (ITA)
AVAR: Christopher Kavanagh (ENG)
Referee Observer: Murat Ilgaz (TUR)
Manchester United – Villarreal CF
Referee: Felix Zwayer (GER)
Assistant Referee 1: Rafael Foltyn (GER)
Assistant Referee 2: Marco Achmüller (GER)
Fourth Official: Sven Jablonski (GER)
VAR: Christian Dingert (GER)
AVAR: Bastian Dankert (GER)
Referee Observer: Martin Ingvarsson (SWE)
VfL Wolfsburg – Sevilla FC
Referee: Georgi Kabakov (BUL)
Assistant Referee 1: Martin Margaritov (BUL)
Assistant Referee 2: Diyan Valkov (BUL)
Fourth Official: Ivaylo Stoyanov (BUL)
VAR: Kevin Blom (NED)
AVAR: Willy Delajod (FRA)
Referee Observer: Terje Hauge (NOR)
FC Salzburg – LOSC Lille
Referee: Halil Umut Meler (TUR)
Assistant Referee 1: Mustafa Eyisoy (TUR)
Assistant Referee 2: Cevdet Komurcuoglu (TUR)
Fourth Official: Alper Ulusoy (TUR)
VAR: Mete Kalkavan (TUR)
AVAR: Harm Osmers (GER)
Referee Observer: Vladimir Šajn (SVN)
Juventus – Chelsea
Referee: Jesus Gil Manzano (ESP)
Assistant Referee 1: Diego Barbero Sevilla (ESP)
Assistant Referee 2: Angel Nevado Rodriguez (ESP)
Fourth Official: Jose Munuera Montero (ESP)
VAR: Juan Martinez Munuera (ESP)
AVAR: Pol van Boekel (NED)
Referee Observer: Vitor Melo Pereira (POR)
Referee: Benoît Bastien (FRA, photo)
Assistant Referee 1: Hicham Zakrani (FRA)
Assistant Referee 2: Aurelien Berthomieu (FRA)
Fourth Official: Jeremie Pignard (FRA)
VAR: Willy Delajod (FRA)
AVAR: Massimiliano Irrati (ITA)
Referee Observer: Leslie Irvine (NIR)
Shakhtar Donetsk – Inter Milano
Referee: Istvan Kovacs (ROU)
Assistant Referee 1: Vasile Marinescu (ROU)
Assistant Referee 2: Ovidiu Artene (ROU)
Fourth Official: Andrei Chivulete (ROU)
VAR: Marco Fritz (GER)
AVAR: Ovidiu Hațegan (ROU)
Referee Observer: Jorn West Larsen (DEN)
Paris St. Germain – Manchester City
Referee: Carlos Del Cerro Grande (ESP)
Assistant Referee 1: Pau Cebrian Devis (ESP)
Assistant Referee 2: Roberto Alonso Fernandez (ESP)
Fourth Official: Santiago Jaime Latre (ESP)
VAR: Juan Martinez Munuera (ESP)
AVAR: Christian Dingert (GER)
Referee Observer: Markus Nobs (SUI)
RB Leipzig – Club Brugge
Referee: Slavko Vinčić (SVN)
Assistant Referee 1: Tomaž Klančnik (SVN)
Assistant Referee 2: Andraž Kovačič (SVN)
Fourth Official: Nejc Kajtazović (SVN)
VAR: Paolo Valeri (ITA)
AVAR: Maurizio Mariani (ITA)
Referee Observer: Stefan Messner (AUT)
FC Porto – Liverpool
Referee: Sergei Karasev (RUS)
Assistant Referee 1: Igor Demeshko (RUS)
Assistant Referee 2: Maksim Gavrilin (RUS)
Fourth Official: Vladimir Moskalev (RUS)
VAR: Bastian Dankert (GER)
AVAR: Vitali Meshkov (RUS)
Referee Observer: Haim Jakov (ISR)
AC Milan – Atletico de Madrid
Referee: Cüneyt Çakir (TUR)
Assistant Referee 1: Bahattin Duran (TUR)
Assistant Referee 2: Tarik Ongun (TUR)
Fourth Official: Arda Kardeşler (TUR)
VAR: Abdulkadir Bitigen (TUR)
AVAR: Mete Kalkavan (TUR)
Referee Observer: Guy Goethals (BEL)
Borussia Dortmund – Sporting Clube de Portugal
Referee: Srdjan Jovanović (SRB)
Assistant Referee 1: Uroš Stojković (SRB)
Assistant Referee 2: Milan Mihajlović (SRB)
Fourth Official: Novak Simović (SRB)
VAR: Pol van Boekel (NED)
AVAR: Kevin Blom (NED)
Referee Observer: Domenico Messina (ITA)
Real Madrid – Sheriff Tiraspol
Referee: Lawrence Visser (BEL)
Assistant Referee 1: Rien Vanyzere (BEL)
Assistant Referee 2: Thibaud Nijssen (BEL)
Fourth Official: Bram Van Driessche (BEL)
VAR: Clement Turpin (FRA)
AVAR: Amaury Delerue (FRA)
Referee Observer: Herbert Fandel (GER)
29 September 2021
Atalanta BC – BSC Young Boys
Referee: Felix Brych (GER)
Assistant Referee 1: Mark Borsch (GER)
Assistant Referee 2: Stefan Lupp (GER)
Fourth Official: Daniel Schlager (GER)
VAR: Sascha Stegemann (GER)
AVAR: Deniz Aytekin (GER)
Referee Observer: Sergey Zuev (RUS)
FC Zenit – Malmö FF
Referee: Anastasios Sidiropoulos (GRE)
Assistant Referee 1: Polychronis Kostaras (GRE)
Assistant Referee 2: Lazaros Dimitriadis (GRE)
Fourth Official: Ioannis Papadopoulos (GRE)
VAR: Jose Sanchez Martinez (ESP)
AVAR: Guillermo Cuadra Fernandez (ESP)
Referee Observer: Marian Ružbarsky (SVK)
Bayern München – Dynamo Kyiv
Referee: Marco Guida (ITA)
Assistant Referee 1: Filippo Meli (ITA)
Assistant Referee 2: Giorgio Peretti (ITA)
Fourth Official: Fabio Maresca (ITA)
VAR: Maurizio Mariani (ITA)
AVAR: Paolo Valeri (ITA)
Referee Observer: Juan Fernandez Marin
SL Benfica – FC Barcelona
Referee: Daniele Orsato (ITA)
Assistant Referee 1: Alessandro Giallatini (ITA)
Assistant Referee 2: Ciro Carbone (ITA)
Fourth Official: Daniele Doveri (ITA)
VAR: Massimiliano Irrati (ITA)
AVAR: Christopher Kavanagh (ENG)
Referee Observer: Murat Ilgaz (TUR)
Manchester United – Villarreal CF
Referee: Felix Zwayer (GER)
Assistant Referee 1: Rafael Foltyn (GER)
Assistant Referee 2: Marco Achmüller (GER)
Fourth Official: Sven Jablonski (GER)
VAR: Christian Dingert (GER)
AVAR: Bastian Dankert (GER)
Referee Observer: Martin Ingvarsson (SWE)
VfL Wolfsburg – Sevilla FC
Referee: Georgi Kabakov (BUL)
Assistant Referee 1: Martin Margaritov (BUL)
Assistant Referee 2: Diyan Valkov (BUL)
Fourth Official: Ivaylo Stoyanov (BUL)
VAR: Kevin Blom (NED)
AVAR: Willy Delajod (FRA)
Referee Observer: Terje Hauge (NOR)
FC Salzburg – LOSC Lille
Referee: Halil Umut Meler (TUR)
Assistant Referee 1: Mustafa Eyisoy (TUR)
Assistant Referee 2: Cevdet Komurcuoglu (TUR)
Fourth Official: Alper Ulusoy (TUR)
VAR: Mete Kalkavan (TUR)
AVAR: Harm Osmers (GER)
Referee Observer: Vladimir Šajn (SVN)
Juventus – Chelsea
Referee: Jesus Gil Manzano (ESP)
Assistant Referee 1: Diego Barbero Sevilla (ESP)
Assistant Referee 2: Angel Nevado Rodriguez (ESP)
Fourth Official: Jose Munuera Montero (ESP)
VAR: Juan Martinez Munuera (ESP)
AVAR: Pol van Boekel (NED)
Referee Observer: Vitor Melo Pereira (POR)