FC Sevilla – FC Salzburg
Referee: Aleksei Kulbakov (BLR, photo)
Assistant Referee 1: Dmitri Zhuk (BLR)
Assistant Referee 2: Oleg Maslyanko (BLR)
Fourth Official: Denis Scherbakov (BLR)
VAR: Bastian Dankert (GER)
AVAR: Tomasz Kwiatkowski (POL)
Referee Observer: Jon Skjervold (NOR)
BSC Young Boys – Manchester United
Referee: François Letexier (FRA)
Assistant Referee 1: Cyril Mugnier (FRA)
Assistant Referee 2: Mehdi Rahmouni (FRA)
Fourth Official: Thomas Leonard (FRA)
VAR: Willy Delajod (FRA)
AVAR: Massimiliano Irrati (ITA)
Referee Observer: Jan Wegereef (NED)
Dynamo Kyiv – SL Benfica
Referee: Anthony Taylor (ENG)
Assistant Referee 1: Gary Beswick (ENG)
Assistant Referee 2: Adam Nunn (ENG)
Fourth Official: Craig Pawson (ENG)
VAR: Christopher Kavanagh (ENG)
AVAR: Jarred Gillett (AUS)
Referee Observer: Stefano Podeschi (SMR)
FC Barcelona – Bayern München
Referee: Michael Oliver (ENG)
Assistant Referee 1: Stuart Burt (ENG)
Assistant Referee 2: Simon Peter Bennett (ENG)
Fourth Official: Darren England (ENG)
VAR: Stuart Attwell (ENG)
AVAR: Paul Tierney (ENG)
Referee Observer: Francesco Bianchi (SUI)
Villarreal CF – Atalanta BC
Referee: Clement Turpin (FRA)
Assistant Referee 1: Nicolas Danos (FRA)
Assistant Referee 2: Cyril Gringore (FRA)
Fourth Official: Jeremie Pignard (FRA)
VAR: Jerôme Brisard (FRA)
AVAR: Stephanie Frappart (FRA)
Referee Observer: Alain Hamer (LUX)
LOSC Lille – VfL Wolfsburg
Referee: Danny Makkelie (NED)
Assistant Referee 1: Hessel Streegstra (NED)
Assistant Referee 2: Jan de Vries (NED)
Fourth Official: Allard Lindhout (NED)
VAR: Kevin Blom (NED)
AVAR: Pol van Boekel (NED)
Referee Observer: Darko Čeferin (SVN)
Malmö FF – Juventus
Referee: Artur Soares Dias (POR)
Assistant Referee 1: Rui Barbosa (POR)
Assistant Referee 2: Paulo Soares (POR)
Fourth Official: Hugo Moreira (POR)
VAR: Joao Pinheiro (POR)
AVAR: Luis Godinho (POR)
Referee Observer: Tomasz Mikulski (POL)
Chelsea FC – FC Zenit
Referee: Bartosz Frankowski (POL)
Assistant Referee 1: Marcin Boniek (POL)
Assistant Referee 2: Jakub Winkler (POL)
Fourth Official: Krzysztof Jakubik (POL)
VAR: Marco Fritz (GER)
AVAR: Marco Di Bello (ITA)
Referee Observer: Kyros Vassaras (GRE)
15 September 2021
Beşiktaş JK – Borussia Dortmund
Referee: Antonio Mateu Lahoz (ESP)
Assistant Referee 1: Pau Cebrian Devis (ESP)
Assistant Referee 2: Roberto Diaz Perez (ESP)
Fourth Official: Javier Alberola Rojas (ESP)
VAR: Juan Martinez Munuera (ESP)
AVAR: Ricardo De Burgos Bengoechea (ESP)
Referee Observer: Ichko Lozev (BUL)
Sheriff Tiraspol – Shakhtar Donetsk
Referee: Deniz Aytekin (GER)
Assistant Referee 1: Christian Dietz (GER)
Assistant Referee 2: Stefan Lupp (GER)
Fourth Official: Martin Petersen (GER)
VAR: Christian Dingert (GER)
AVAR: Markus Sinn (GER)
Referee Observer: Emil Bozhinovski (MKD)
Club Brugge – Paris St. Germain
Referee: Sandro Schärer (SUI)
Assistant Referee 1: Stephane De Almeida (SUI)
Assistant Referee 2: Bekim Zogaj (SUI)
Fourth Official: Fedayi San (SUI)
VAR: Massimiliano Irrati (ITA)
AVAR: Stuart Attwell (ENG)
Referee Observer: Matteo Trefoloni (ITA)
Manchester City – RB Leipzig
Referee: Serdar Gözübüyük (NED)
Assistant Referee 1: Joost van Zuilen (NED)
Assistant Referee 2: Johan Balder (NED)
Fourth Official: Jeroen Manschot (NED)
VAR: Pol van Boekel (NED)
AVAR: Stephanie Frappart (FRA)
Referee Observer: Hugh Dallas (SCO)
Atletico de Madrid – FC Porto
Referee: Ovidiu Hațegan (ROU)
Assistant Referee 1: Radu Ghinguleac (ROU)
Assistant Referee 2: Sebastian Gheorghe (ROU)
Fourth Official: Radu Petrescu (ROU)
VAR: Marco Di Bello (ITA)
AVAR: Jerôme Brisard (FRA)
Referee Observer: Elmir Pilav (BIH)
Liverpool FC – AC Milan
Referee: Szymon Marciniak (POL)
Assistant Referee 1: Pawel Sokolnicki (POL)
Assistant Referee 2: Tomasz Listkiewicz (POL)
Fourth Official: Tomasz Musial (POL)
VAR: Tomasz Kwiatkowski (POL)
AVAR: Bastian Dankert (GER)
Referee Observer: Lutz Michael Fröhlich (GER)
Sporting CP – AFC Ajax
Referee: Jose Sanchez Martinez (ESP)
Assistant Referee 1: Raul Cabanero Martinez (ESP)
Assistant Referee 2: Inigo Prieto Lopez (ESP)
Fourth Official: Cesar Soto Grado (ESP)
VAR: Alejandro Hernandez Hernandez (ESP)
AVAR: Guillermo Cuadra Fernandez (ESP)
Referee Observer: Frank De Bleeckere (BEL)
Inter Milano – Real Madrid
Referee: Daniel Siebert (GER)
Assistant Referee 1: Rafael Foltyn (GER)
Assistant Referee 2: Christian Gittelmann (GER)
Fourth Official: Daniel Schlager (GER)
VAR: Marco Fritz (GER)
AVAR: Harm Osmers (GER)
Referee Observer: Vladimir Šajn (SVN)