Brazil – Ecuador
Referee: Roberto Tobar (CHI, photo)
Assistant Referee 1: Christian Schiemann (CHI)
Assistant Referee 2: Claudio Rios (CHI)
Fourth Official: Andres Cunha (URU)
VAR: Julio Bascunan (CHI)
AVAR: Cristian Garay (CHI)
Referee Assessor: Amelio Andino (PAR)
Venezuela – Peru
Referee: Patricio Loustau (ARG)
Assistant Referee 1: Gabriel Chade (ARG)
Assistant Referee 2: Eduardo Cardozo (PAR)
Fourth Official: Eber Aquino (PAR)
VAR: Derlis Lopez (PAR)
AVAR: Juan Benitez (PAR)
Referee Assessor: Enrique Caceres (PAR)
28 June 2021
Uruguay – Paraguay
Referee: Raphael Claus (BRA)
Assistant Referee 1: Danilo Manis (BRA)
Assistant Referee 2: Bruno Pires (BRA)
Fourth Official: Guillermo Guerrero (ECU)
VAR: Wagner Reway (BRA)
AVAR: Christian Lescano (ECU)
Referee Assessor: Emerson Carvalho (BRA)
Bolivia – Argentina
Referee: Andres Rojas (COL)
Assistant Referee 1: John Leon (COL)
Assistant Referee 2: Jonny Bossio (PER)
Fourth Official: Diego Haro (PER)
VAR: Ricardo De Burgos Bengoetxea (ESP)
AVAR: Alexander Guzman (COL)
Referee Assessor: Roberto Perassi (BRA)