Club America – Cruz Azul
Referee: Joseph Dickerson (USA, photo)
Los Angeles Galaxy – Tigres UANL
Referee: Kwinsi Williams (TRI)
Vancouver Whitecaps – Pumas UNAM
Referee: Keylor Herrera (CRC)
Los Angeles FC – Inter Miami
Referee: Oshane Nation (JAM)
Second Leg, 8-9 April 2025
Tigres UANL – Los Angeles Galaxy
Referee: Selvin Brown (HON)
Cruz Azul – Club America
Referee: Ismael Cornejo (SLV)
Inter Miami – Los Angeles FC
Referee: Cesar Ramos (MEX)
Pumas UNAM – Vancouver Whitecaps
Referee: Walter Lopez (GUA)
