23 May 2021
Raja Casablanca – Orlando Pirates
Referee: Mustapha Ghorbal (ALG, photo)
Assistant Referee 1: Abdelhak Etchiali (ALG)
Assistant Referee 2: Mokrane Gourari (ALG)
Fourth Official: Mehdi Abid Charef (ALG)
JS Kabylie – CS Sfaxien
Referee: Redouane Jiyed (MAR)
Assistant Referee 1: Lahcen Azgaou (MAR)
Assistant Referee 2: Mustapha Akerkad (MAR)
Fourth Official: Samir Guezzaz (MAR)
Enyimba – Pyramids
Referee: Sadok Selmi (TUN)
Assistant Referee 1: Khalil Hassani (TUN)
Assistant Referee 2: Aymen Ismail (TUN)
Fourth Official: Haythem Guirat (TUN)
Jaraaf – Coton Sport
Referee: Boubou Traore (MLI)
Assistant Referee 1: Modibo Samake (MLI)
Assistant Referee 2: Habib Sanou (BFA)
Fourth Official: Mahamadou Keita (MLI)