23 August 2018
Partizan – Beşiktaş
Referee: Ivan Kružliak (SVK, photo)
Assistant Referee 1: Tomáš Somoláni (SVK)
Assistant Referee 2: Branislav Hancko (SVK)
Fourth Official: Filip Glova (SVK)
Referee Observer: Bo Karlsson (SWE)
Zenit – Molde
Referee: Deniz Aytekin (GER)
Assistant Referee 1: Eduard Beitinger (GER)
Assistant Referee 2: Rafael Foltyn (GER)
Fourth Official: Harm Osmers (GER)
Referee Observer: Sabri Çelik (TUR)
Torpedo Kutaisi – PFC Ludogorets
Referee: Hüseyin Göçek (TUR)
Assistant Referee 1: Kemal Yılmaz (TUR)
Assistant Referee 2: Mustafa Eyisoy (TUR)
Fourth Official: Koray Gençerler (TUR)
Referee Observer: Petteri Kari (FIN)
Sigma Olomouc – Sevilla FC
Referee: Robert Madden (SCO)
Assistant Referee 1: Francis Connor (SCO)
Assistant Referee 2: Douglas Potter (SCO)
Fourth Official: Donald Robertson (SCO)
Referee Observer: Stefan Messner (AUT)
AS Trenčín – AEK Larnaca
Referee: Antonio Mateu Lahoz (ESP)
Assistant Referee 1: Pau Cebrián Devís (ESP)
Assistant Referee 2: Javier Aguilar Rodríguez (ESP)
Fourth Official: Ricardo de Burgos Bengoetxea (ESP)
Referee Observer: Stephen Lodge (ENG)
Apoel – Astana
Referee: Daniel Siebert (GER)
Assistant Referee 1: Jan Seidel (GER)
Assistant Referee 2: Lasse Koslowski (GER)
Fourth Official: Frank Willenborg (GER)
Referee Observer: Andreas Schluchter (SUI)
Suduva – Celtic
Referee: Ivan Bebek (CRO)
Assistant Referee 1: Tomislav Petrović (CRO)
Assistant Referee 2: Miro Grgić (CRO)
Fourth Official: Mario Zebec (CRO)
Referee Observer: Alfredo Trentalange (ITA)
Sheriff Tiraspol – Qarabağ
Referee: Harald Lechner (AUT)
Assistant Referee 1: Andreas Heidenreich (AUT)
Assistant Referee 2: Maximilian Kolbitsch (AUT)
Fourth Official: Julian Weinberger (AUT)
Referee Observer: Volodymyr Petrov (UKR)
Sarpsborg FF – Maccabi Tel Aviv
Referee: Vladislav Bezborodov (RUS)
Assistant Referee 1: Valeriy Danchenko (RUS)
Assistant Referee 2: Maksim Gavrilin (RUS)
Fourth Official: Aleksey Yes'kov (RUS)
Referee Observer: Andrejs Sipailo (LVA)
Malmö FF – Midtjylland
Referee: Srdjan Jovanović (SRB)
Assistant Referee 1: Uroš Stojković (SRB)
Assistant Referee 2: Milan Mihajlović (SRB)
Fourth Official: Novak Simović (SRB)
Referee Observer: Michális Koukoulákis (GRE)
FC Basel – Apollon Limassol
Referee: Matej Jug (SVN)
Assistant Referee 1: Manuel Vidali (SVN)
Assistant Referee 2: Grega Kordež (SVN)
Fourth Official: Nejc Kajtazovič (SVN)
Referee Observer: Jon Skjervold (NOR)
Atalanta – København
Referee: Pavel Královec (CZE)
Assistant Referee 1: Ivo Nádvorník (CZE)
Assistant Referee 2: Kamil Hájek (CZE)
Fourth Official: Petr Ardeleánu (CZE)
Referee Observer: Nuno Castro (POR)
Olympiakós – Burnley
Referee: Slavko Vinčič (SVN)
Assistant Referee 1: Tomaž Klančnik (SVN)
Assistant Referee 2: Andraž Kovačič (SVN)
Fourth Official: Rade Obrenovič (SVN)
Referee Observer: Rune Pedersen (NOR)
Olimpija Ljubljana – Spartak Trnava
Referee: Craig Pawson (ENG)
Assistant Referee 1: Stephen Child (ENG)
Assistant Referee 2: Lee Betts (ENG)
Fourth Official: Christopher Kavanagh (ENG)
Referee Observer: Luciano Luci (ITA)
F91 Dudelange – CFR Cluj
Referee: Andreas Ekberg (SWE)
Assistant Referee 1: Mehmet Culum (SWE)
Assistant Referee 2: Stefan Hallberg (SWE)
Fourth Official: Kristoffer Karlsson (SWE)
Referee Observer: Laurent Duhamel (FRA)
Rapid Wien – FCSB
Referee: William Collum (SCO)
Assistant Referee 1: David McGeachie (SCO)
Assistant Referee 2: Douglas Ross (SCO)
Fourth Official: Nicolas Walsh (SCO)
Referee Observer: Sándor Piller (HUN)
KRC Genk – Brøndby IF
Referee: Andris Treimanis (LVA)
Assistant Referee 1: Haralds Gudermanis (LVA)
Assistant Referee 2: Aleksejs Spasjonņikovs (LVA)
Fourth Official: Aleksandrs Golubevs (LVA)
Referee Observer: Manuel Mejuto González (ESP)
Zorya Luhansk – RB Leipzig
Referee: Benoît Bastien (FRA)
Assistant Referee 1: Frédéric Haquette (FRA)
Assistant Referee 2: Hicham Zakrani (FRA)
Fourth Official: Benoît Millot (FRA)
Referee Observer: Alain Hamer (LUX)
KAA Gent – Girondins de Bordeaux
Referee: Aliyar Ağayev (AZE)
Assistant Referee 1: Zeynal Zeynalov (AZE)
Assistant Referee 2: Rza Mammadov (AZE)
Fourth Official: Orxan Mammadov (AZE)
Referee Observer: Michael Ross (NIR)
Rangers – Ufa
Referee: Daniel Stefański (POL)
Assistant Referee 1: Marcin Boniek (POL)
Assistant Referee 2: Dawid Golis (POL)
Fourth Official: Zbigniew Dobrynin (POL)
Referee Observer: Michel Piraux (BEL)
Rosenborg – Shkëndija
Referee: Orel Grinfeld (ISR)
Assistant Referee 1: Dvir Shimon (ISR)
Assistant Referee 2: Roy Hassan (ISR)
Fourth Official: Alon Yefet (ISR)
Referee Observer: Martin Ingvarsson (SWE)