13 September 2016
Sporting KC – Vancouver Whitecaps
Referee: Ricardo Montero (CRC, photo)
Assistant Referee 1: Juan Mora (CRC)
Assistant Referee 2: Octavio Jara (CRC)
Fourth Official: Henry Bejarano (CRC)
Police United – Pachuca
Referee: Wilson DaCosta (BAH)
Assistant Referee 1: Jeremy Holland (BAH)
Assistant Referee 2: Sean Thompson (BAH)
Fourth Official: William Anderson (PUR)
Real Esteli – Suchitepequez
Referee: Kevin Morrison (JAM)
Assistant Referee 1: Garnet Page (JAM)
Assistant Referee 2: Jean Moreau (HAI)
Fourth Official: Keon Yorke (TRI)
14 September 2016
Arabe Unido – Monterrey
Referee: Ismail Elfath (USA)
Assistant Referee 1: Charles Morgante (USA)
Assistant Referee 2: Corey Rockwell (USA)
Fourth Official: Edvin Jurisevic (USA)
Saprissa – Portland
Referee: Yadel Martinez (CUB)
Assistant Referee 1: Hiran Dopico (CUB)
Assistant Referee 2: Leonardo Sanchez (CUB)
Fourth Official: Marco Brea (CUB)
15 September 2016
NY Red Bulls – Alianza FC
Referee: Oscar Reyna (GUA)
Assistant Referee 1: Marco Diaz (GUA)
Assistant Referee 2: Ronaldo De La Cruz (GUA)
Fourth Official: Mario Escobar (GUA)
H. Progreso – Pumas
Referee: Walter Quesada (CRC)
Assistant Referee 1: Carlos Fernandez (CRC)
Assistant Referee 2: Hermenerito Leal (GUA)
Fourth Official: Juan Guerro (GUA)
Herediano – Plaza Amador
Referee: Hector Rodriguez (HON)
Assistant Referee 1: Jesus Tabora (HON)
Assistant Referee 2: Melvyn Cruz (HON)
Fourth Official: Raul Castro (HON)