Copa Libertadores – Semi-finals (First Leg)

6 July 2016
Sao Paulo – Atletico
Referee: Mauro Vigliano (ARG, photo)
Assistant Referee 1: Juan Belatti (ARG)
Assistant Referee 2: Gustavo Rossi (ARG)
Fourth Official: Fernando Rapallini (ARG)
Referee Observer: Jorge Larrionda (URU)

7 July 2016
Independiente del Valle – Boca Juniors
Referee: Wilmar Roldan (COL)
Assistant Referee 1: Alexander Guzman (COL)
Assistant Referee 2: Christian De la Cruz (COL)
Fourth Official: Wilson Lamouroux (COL)
Referee Observer: Wilson Seneme (BRA)