25 February 2016
Athletic Bilbao – Olympique Marseille
Referee: Aleksei Kulbakov (BLR)
Assistant Referee 1: Vitali Malyutsin (BLR)
Assistant Referee 2: Oleg Maslyanka (BLR)
Additional AR 1: Sergei Tsinkevich (BLR)
Additional AR 2: Denis Scherbakov (BLR)
Fourth Official: Dmitri Zhuk (BLR)
Referee Observer: László Vagner (HUN)
Braga – Sion
Referee: Liran Liany (ISR)
Assistant Referee 1: Danny Krasikow (ISR)
Assistant Referee 2: David Biton (ISR)
Additional AR 1: Roi Reinshreiber (ISR)
Additional AR 2: Eli Hacmon (ISR)
Fourth Official: Nissan Davidy (ISR)
Referee Observer: Murat Ilgaz (TUR)
Lokomotiv Moskva – Fenerbahçe
Referee: Ivan Kružliak (SVK)
Assistant Referee 1: Martin Balko (SVK)
Assistant Referee 2: Tomaš Somolani (SVK)
Additional AR 1: Peter Kralović (SVK)
Additional AR 2: Mário Vlk (SVK)
Fourth Official: Tomaš Mokoš (SVK)
Referee Observer: Hans Reijgwart (NED)
Schalke – Shakhtar Donetsk
Referee: Matej Jug (SVN)
Assistant Referee 1: Matej Žunič (SVN)
Assistant Referee 2: Robert Vukan (SVN)
Additional AR 1: Mitja Žganec (SVN)
Additional AR 2: Dejan Balažič (SVN)
Fourth Official: Bojan Ul (SVN)
Referee Observer: Matteo Trefoloni (ITA)
Liverpool – Augsburg
Referee: Clément Turpin (FRA)
Assistant Referee 1: Frédéric Cano (FRA)
Assistant Referee 2: Nicolas Danos (FRA)
Additional AR 1: Benoît Bastien (FRA)
Additional AR 2: Fredy Fautrel (FRA)
Fourth Official: Cyril Gringore (FRA)
Referee Observer: Bo Karlsson (SWE)
Krasnodar – Sparta Praha
Referee: Stefan Johannesson (SWE)
Assistant Referee 1: Fredrik Nilsson (SWE)
Assistant Referee 2: Mehmet Culum (SWE)
Additional AR 1: Andreas Ekberg (SWE)
Additional AR 2: Kristoffer Karlsson (SWE)
Fourth Official: Magnus Sjöblom (SWE)
Referee Observer: Stefan Ormandjiev (BUL)
Lazio – Galatasaray
Referee: Vladislav Bezborodov (RUS)
Assistant Referee 1: Nikolai Golubev (RUS)
Assistant Referee 2: Maksim Gavrilin (RUS)
Additional AR 1: Aleksei Eskov (RUS)
Additional AR 2: Igor Fedotov (RUS)
Fourth Official: Valeri Danchenko (RUS)
Referee Observer: Christos Skapoullis (CYP)
Bayer Leverkusen – Sporting Lisbon
Referee: Ruddy Buquet (FRA)
Assistant Referee 1: Guillaume Debart (FRA)
Assistant Referee 2: Laurent Stien (FRA)
Additional AR 1: Tony Chapron (FRA)
Additional AR 2: Nicolas Rainville (FRA)
Fourth Official: Hicham Zakrani (FRA)
Referee Observer: Manuel Mejuto González (ESP)
Rapid Wien - Valencia
Referee: Paolo Tagliavento (ITA)
Assistant Referee 1: Mauro Tonolini (ITA)
Assistant Referee 2: Fabiano Preti (ITA)
Additional AR 1: Paolo Mazzoleni (ITA)
Additional AR 2: Davide Massa (ITA)
Fourth Official: Andrea Padovan (ITA)
Referee Observer: Tomasz Mikulski (POL)
Tottenham Hotspur – Fiorentina
Referee: Ovidiu Haţegan (ROU)
Assistant Referee 1: Octavian Șovre (ROU)
Assistant Referee 2: Sebastian Gheorghe (ROU)
Additional AR 1: Alexandru Tudor (ROU)
Additional AR 2: Sebastian Colţescu (ROU)
Fourth Official: Radu Ghinguleac (ROU)
Referee Observer: Terje Hauge (NOR)
FC Porto – Borussia Dortmund
Referee: Mark Clattenburg (ENG)
Assistant Referee 1: Simon Beck (ENG)
Assistant Referee 2: Jake Collin (ENG)
Additional AR 1: Anthony Taylor (ENG)
Additional AR 2: Andre Marriner (ENG)
Fourth Official: Stuart Burt (ENG)
Referee Observer: Francesco Bianchi (SUI)
SSC Napoli – Villarreal
Referee: Deniz Aytekin (GER)
Assistant Referee 1: Guido Kleve (GER)
Assistant Referee 2: Stefan Lupp (GER)
Additional AR 1: Tobias Welz (GER)
Additional AR 2: Benjamin Brand (GER)
Fourth Official: Rafael Foltyn (GER)
Referee Observer: Michel Vautrot (FRA)
FC Basel – AS Saint Étienne
Referee: Danny Makkelie (NED)
Assistant Referee 1: Mario Diks (NED)
Assistant Referee 2: Hessel Steegstra (NED)
Additional AR 1: Kevin Blom (NED)
Additional AR 2: Dennis Higler (NED)
Fourth Official: Bas van Dongen (NED)
Referee Observer: Roberto Rosetti (ITA)
Molde – Sevilla
Referee: Robert Madden (SCO)
Assistant Referee 1: Douglas Ross (SCO)
Assistant Referee 2: Alastair Mather (SCO)
Additional AR 1: Andrew Dallas (SCO)
Additional AR 2: Donald Robertson (SCO)
Fourth Official: David McGeachie (SCO)
Referee Observer: Ryszard Wójcik (POL)
Olympiacos – Anderlecht
Referee: Arnold Hunter (NIR)
Assistant Referee 1: Richard Storey (NIR)
Assistant Referee 2: Gareth Eakin (NIR)
Additional AR 1: Raymond Crangle (NIR)
Additional AR 2: Mervyn Smyth (NIR)
Fourth Official: Stephen Bell (NIR)
Referee Observer: Herbert Fandel (GER)
Manchester United – Midtjylland
Referee: István Vad (HUN)
Assistant Referee 1: István Albert (HUN)
Assistant Referee 2: Peter Berettyán (HUN)
Additional AR 1: Sándor Andó-Szabó (HUN)
Additional AR 2: Jozsef Erdos (HUN)
Fourth Official: László Viszokai (HUN)
Referee Observer: Cyril Zimmermann (SUI)