Referee: Ricardo Marques (BRA, photo)
Assistant Referee 1: Marcio Santiago (BRA)
Assistant Referee 2: Rodrigo Joia (BRA)
Fourth Official: Oscar Maldonado (BOL)
Nacional – Liga de Loja
Referee: Patricio Polic (CHI)
Assistant Referee 1: Sergio Roman (CHI)
Assistant Referee 2: Julio Diaz (CHI)
Fourth Official: Daniel Fedorczuk (URU)
Emelec – Olimpia
Referee: Nestor Pitana (ARG)
Assistant Referee 1: Gustavo Esquivel (ARG)
Assistant Referee 2: Ernesto Uziga (ARG)
Fourth Official: Alfredo Intriago (ECU)
Deportes Tolima – Universidad Catolica
Referee: Victor Rivera (PER)
Assistant Referee 1: Jorge Yupanqui (PER)
Assistant Referee 2: Victor Raez (PER)
Fourth Official: Luis Sanchez (COL)
19 September 2012
Liverpool – Envigado
Referee: Julio Quintana (PAR)
Assistant Referee 1: Milciades Saldivar (PAR)
Assistant Referee 2: Hugo Martinez (PAR)
Fourth Official: Dario Ubriaco (URU)
Barcelona – Cobreloa
Referee: Martin Vazquez (URU)
Assistant Referee 1: Nicolas Taran (URU)
Assistant Referee 2: Gabriel Popovits (URU)
Fourth Official: Daniel Salazar (ECU)
Cerro Porteno – Mineros Guayana
Referee: Heber Lopes (BRA)
Assistant Referee 1: Marcelo Van Gasse (BRA)
Assistant Referee 2: Carlos Berkenbrock (BRA)
Fourth Official: Ulises Mereles (PAR)
Millonarios – Guarani
Referee: Omar Ponce (ECU)
Assistant Referee 1: Juan Cedeno (ECU)
Assistant Referee 2: Byron Romero (ECU)
Fourth Official: Jose Buitrago (COL)