Real Esteli – Tigres UANL
Referee: Juan Carlos Guerra (GUA, photo)
Assistant Referee 1: Hermenelito Leal (GUA)
Assistant Referee 2: Cesar Ruano (GUA)
Fourth Official: Oscar Reyna (GUA)
Xelaju – W Connection
Referee: Rolando Vidal (PAN)
Assistant Referee 1: Benigno Paneso (PAN)
Assistant Referee 2: Gabriel Victoria (PAN)
Fourth Official: John Pitti (PAN)
Tauro – Real Salt Lake
Referee: Mauricio Morales (MEX)
Assistant Referee 1: Jose Camargo (MEX)
Assistant Referee 2: Alberto Morin (MEX)
Fourth Official: Ricardo Arellano (MEX)
19 September 2012
Aguila – Santos Laguna
Referee: Henry Bejarano (CRC)
Assistant Referee 1: Leonel Leal (CRC)
Assistant Referee 2: Javier Rojas (CRC)
Fourth Official: Jeffrey Solis (CRC)
Marathon – Seattle Sounders
Referee: Marlon Mejia (SLV)
Assistant Referee 1: Hector Recinos (SLV)
Assistant Referee 2: Geovani Garcia (SLV)
Fourth Official: Ruben Medrano (SLV)
Puerto Rico – LA Galaxy
Referee: Raymond Bogle (JAM)
Assistant Referee 1: Ricardo Morgan (JAM)
Assistant Referee 2: Garnet Page (JAM)
Fourth Official: Kevin Thomas (JAM)
20 September 2012
Houston Dynamo – FAS
Referee: Francisco Chacon (MEX)
Assistant Referee 1: Juan Rangel (MEX)
Assistant Referee 2: Salvador Rodriguez (MEX)
Fourth Official: Miguel Flores (MEX)
Municipal – Chorrillo
Referee: Silviu Petrescu (CAN)
Assistant Referee 1: Joe Fletcher (CAN)
Assistant Referee 2: Philippe Briere (CAN)
Fourth Official: Paul Ward (CAN)
