21 February 2012
Arsenal – Zamora
Referee: Enrique Osses (CHI, photo)
Assistant Referee 1: Carlos Astroza (CHI)
Assistant Referee 2: Juan Maturana (CHI)
Fourth Official: Nestor Pitana (ARG)
Penarol – Atletico Nacional
Referee: Carlos Amarilla (PAR)
Assistant Referee 1: Nicolas Yegros (PAR)
Assistant Referee 2: Carlos Caceres (PAR)
Fourth Official: Hector Martinez (URU)
Bolivar – Union Espanola
Referee: Enrique Caceres (PAR)
Assistant Referee 1: Dario Gaona (PAR)
Assistant Referee 2: Cesar Franco (PAR)
Fourth Official: Johnny Cuellar (BOL)
Cruz Azul – Deportivo Tachira
Referee: Imer Machado (COL)
Assistant Referee 1: Humberto Clavijo (COL)
Assistant Referee 2: Wilmar Navarro (COL)
Fourth Official: Jorge Gasso Flores (MEX)
22 February 2012
Universidad Chile – Godoy Cruz
Referee: Wilson Seneme (BRA)
Assistant Referee 1: Emerson Carvalho (BRA)
Assistant Referee 2: Marcelo Van Gasse (BRA)
Fourth Official: Claudio Puga (CHI)
Velez Sarsfield – Chivas Guadalajara
Referee: Leandro Vuaden (BRA)
Assistant Referee 1: Roberto Braatz (BRA)
Assistant Referee 2: Rodrigo Joia (BRA)
Fourth Official: Sergio Pezzotta (ARG)
23 February 2012
Olimpia – Lanus
Referee: Dario Ubriaco (URU)
Assistant Referee 1: Mauricio Espinosa (URU)
Assistant Referee 2: Miguel Nievas (URU)
Fourth Official: Antonio Arias (PAR)
The Strongest – Juan Aurich
Referee: Federico Beligoy (ARG)
Assistant Referee 1: Ernesto Uziga (ARG)
Assistant Referee 2: Ivan Nunez (ARG)
Fourth Official: Oscar Maldonado (BOL)
Universidad Catolica – Atletico Junior
Referee: Pablo Lunati (ARG)
Assistant Referee 1: Gustavo Rossi (ARG)
Assistant Referee 2: Ariel Bustos (ARG)
Fourth Official: Jorge Osorio (CHI)