14 February 2012
Defensor Sporting – Deportivo Quito
Referee: Heber Lopes (BRA, photo)
Assistant Referee 1: Altemir Hausmann (BRA)
Assistant Referee 2: Rodrigo Joia (BRA)
Fourth Official: Daniel Fedorczuk (URU)
Zamora – Boca Juniors
Referee: Jose Buitrago (COL)
Assistant Referee 1: Alexander Guzman (COL)
Assistant Referee 2: Eduardo Díaz (COL)
Fourth Official: Candelario Andaracia (VEN)
Atletico Nacional – Universidad de Chile
Referee: Víctor Carrillo (PER)
Assistant Referee 1: Jonny Bossio (PER)
Assistant Referee 2: Cesar Escano (PER)
Fourth Official: Adrian Velez (COL)
15 February 2012
The Strongest – Santos
Referee: Carlos Vera (ECU)
Assistant Referee 1: Christian Lescano (ECU)
Assistant Referee 2: Luis Alavardo (ECU)
Fourth Official: Johnny Cuellar (BOL)
Deportivo Tachira – Corinthians
Referee: Wilmar Roldan (COL)
Assistant Referee 1: Humberto Clavijo (COL)
Assistant Referee 2: Wilmar Navarro (COL)
Fourth Official: Marlon Escalante (VEN)
CA Lanus – Flamengo
Referee: Roberto Silvera (URU)
Assistant Referee 1: Mauricio Espinosa (URU)
Assistant Referee 2: Nicolas Taran (URU)
Fourth Official: German Delfino (ARG)
16 February 2012
Nacional Montevideo – Libertad
Referee: Saul Laverni (ARG)
Assistant Referee 1: Gustavo Rossi (ARG)
Assistant Referee 2: Ernesto Uziga (ARG)
Fourth Official: Liber Prudente (URU)
Godoy Cruz – Penarol
Referee: Raul Orosco (BOL)
Assistant Referee 1: Arol Valda (BOL)
Assistant Referee 2: Wilson Arellano (BOL)
Fourth Official: Federico Beligoy (ARG)