Panathinaikos – Real Betis
Referee: Szymon Marciniak POL (photo)
Assistant Referee 1: Tomasz Listkiewicz POL
Assistant Referee 2: Adam Kupsik POL
Fourth Official: Pawel Raczkowski POL
VAR: Jarred Gillett ENG
AVAR: Matthew Donohue ENG
Referee Observer: Dejan Filipović SRB
Bologna FC – AS Roma
Referee: Sven Jablonski GER
Assistant Referee 1: Eduard Beitinger GER
Assistant Referee 2: Lasse Koslowski GER
Fourth Official: Harm Osmers GER
VAR: Bastian Dankert GER
AVAR: Robert Schröder GER
Referee Observer: Rune Pedersen NOR
VfB Stuttgart – FC Porto
Referee: Donatas Rumšas LTU
Assistant Referee 1: Aleksandr Radiuš LTU
Assistant Referee 2: Dovydas Sužiedėlis LTU
Fourth Official: Manfredas Lukjančukas LTU
VAR: Dennis Higler NED
AVAR: Pol van Boekel NED
Referee Observer: Hugh Dallas SCO
LOSC Lille – Aston Villa
Referee: José Sánchez Martinez ESP
Assistant Referee 1: Raúl Cabañero Martinez ESP
Assistant Referee 2: Iñigo Prieto Lopez ESP
Fourth Official: Alejandro Muñiz Ruiz ESP
VAR: César Soto Grado ESP
AVAR: Carlos Del Cerro Grande ESP
Referee Observer: Vladimir Antonov MDA
Ferencvarosi TC – SC Braga
Referee: Nicholas Walsh SCO
Assistant Referee 1: Francis Connor SCO
Assistant Referee 2: Daniel McFarlane SCO
Fourth Official: Donald Robertson SCO
VAR: Darren England ENG
AVAR: Kevin Clancy SCO
Referee Observer: Cüneyt Çakir TUR
KRC Genk – SC Freiburg
Referee: Christopher Kavanagh ENG
Assistant Referee 1: Daniel Cook ENG
Assistant Referee 2: Ian Hussin ENG
Fourth Official: Samuel Barrott ENG
VAR: Stuart Attwell ENG
AVAR: Peter Bankes ENG
Referee Observer: Vítor Melo Pereira POR
Celta de Vigo – Olympique Lyonnais
Referee: Erik Lambrechts BEL
Assistant Referee 1: Jo de Weirdt BEL
Assistant Referee 2: Kevin Monteny BEL
Fourth Official: Nathan Verboomen BEL
VAR: Bram Van Driessche BEL
AVAR: Jan Boterberg BEL
Referee Observer: Elmir Pilav BIH
Nottingham Forrest – FC Midtjylland
Referee: Rade Obrenović SVN
Assistant Referee 1: Jure Praprotnik SVN
Assistant Referee 2: Grega Kordež SVN
Fourth Official: Martin Matoša SVN
VAR: Matej Jug SVN
AVAR: Rob Dieperink NED
Referee Observer: Luis Medina Cantalejo ESP