3 May 2016Atlético Nacional – Huracán
Referee: Jose Argote (VEN, photo)
Assistant Referee 1: Jorge Urrego (VEN)
Assistant Referee 2: Luis Sanchez (VEN)
Fourth Official: Marlon Escalante (VEN)
Referee Observer: Otalvaro Polanco (COL)
Pumas Unam – Deportivo Tachira
Referee: Patricio Polic (CHI)
Assistant Referee 1: Francisco Mondria (CHI)
Assistant Referee 2: Raul Orellana (CHI)
Fourth Official: Claudio Puga (CHI)
Referee Observer: Edgardo Codesal (MEX)
4 May 2016
Toluca – São Paulo
Referee: Wilson Lamouroux (COL)
Assistant Referee 1: Wilmar Navarro (COL)
Assistant Referee 2: Alexander León (COL)
Fourth Official: Gustavo Murillo (COL)
Referee Observer: Gilberto Alcalá (MEX)
River Plate – Independiente Del Valle
Referee: Wilmar Roldan (COL)
Assistant Referee 1: Eduardo Diaz (COL)
Assistant Referee 2: Dionisio Ruiz (COL)
Fourth Official: Luis Sanchez (COL)
Referee Observer: Miguel Scime (ARG)
Corinthians – Nacional
Referee: Néstor Pitana (ARG)
Assistant Referee 1: Diego Bonfa (ARG)
Assistant Referee 2: Christian Navarro (ARG)
Fourth Official: Jorge Baliño (ARG)
Referee Observer: Ednilson Corona (BRA)
Atlético Mineiro – Racing
Referee: Daniel Fedorczuk (URU)
Assistant Referee 1: Mauricio Espinosa (URU)
Assistant Referee 2: Richard Trinidad (URU)
Fourth Official: Leodan Gonzalez (URU)
Referee Observer: Juliano Lobato (BRA)
5 May 2016
Rosario Central – Gremio
Referee: Enrique Caceres (PAR)
Assistant Referee 1: Carlos Caceres (PAR)
Assistant Referee 2: Dario Gaona (PAR)
Fourth Official: Mario Diaz De Vivar (PAR)
Referee Observer: Luis Pasturenzi (ARG)
Boca Juniors – Cerro Porteño
Referee: Wilton Sampaio (BRA)
Assistant Referee 1: Kleber Gil (BRA)
Assistant Referee 2: Bruno Boschilia (BRA)
Fourth Official: Anderson Daronco (BRA)
Referee Observer: Miguel Scime (ARG)