26 April 2016
Huracán – Atlético Nacional
Referee: Patricio Polic (CHI, photo)
Assistant Referee 1: Carlos Astroza (CHI)
Assistant Referee 2: Christian Schiemann (CHI)
Fourth Official: Claudio Puga (CHI)
Referee Observer: Miguel Scime (ARG)
Deportivo Táchira – Pumas Unam
Referee: Óscar Maldonado (BOL)
Assistant Referee 1: Wilson Arellano (BOL)
Assistant Referee 2: José Antelo (BOL)
Fourth Official: José Jordan (BOL)
Referee Observer: Adrián Gómez (VEN)
27 April 2016
Racing – Atlético Mineiro
Referee: Julio Quintana (PAR)
Assistant Referee 1: Eduardo Cardozo (PAR)
Assistant Referee 2: Roberto Cañete (PAR)
Fourth Official: Mario Diaz de Vivar (PAR)
Referee Observer: Carlos Coradina (ARG)
Gremio – Rosario Central
Referee: Víctor Carrillo (PER)
Assistant Referee 1: Jonny Bossio (PER)
Assistant Referee 2: Braulio Cornejo (PER)
Fourth Official: Miguel Santivañez (PER)
Referee Observer: José Mocellin (BRA)
Nacional – Corinthians
Referee: Patricio Loustau (ARG)
Assistant Referee 1: Gustavo Rossi (ARG)
Assistant Referee 2: Ariel Scime (ARG)
Fourth Official: Silvio Trucco (ARG)
Referee Observer: Martín Vázquez (URU)
28 April 2016
Independiente del Valle – River Plate
Referee: Heber Lopes (BRA)
Assistant Referee 1: Rodrigo Correa (BRA)
Assistant Referee 2: Guillerme Dias (BRA)
Fourth Official: Raphael Claus (BRA)
Referee Observer: Bomer Fierro (ECU)
Sao Paulo – Toluca
Referee: Jonathan Fuentes (URU)
Assistant Referee 1: Miguel Nievas (URU)
Assistant Referee 2: Richard Trinidad (URU)
Fourth Official: Esteban Ostojich (URU)
Referee Observer: Roberto Perassi (BRA)
Cerro Porteño – Boca Juniors
Referee: Francisco Chacon (MEX)
Assistant Referee 1: José Camargo (MEX)
Assistant Referee 2: Salvador Rodriguez (MEX)
Fourth Official: Paul Delgadillo (MEX)
Referee Observer: Ubaldo Aquino (PAR)