Ajax – Sevilla
Referee: Daniel Siebert (GER, photo)
Assistant Referee 1: Jan Seidel (GER)
Assistant Referee 2: Eduard Beitinger (GER)
Fourth Official: Dennis Higler (NED)
Referee Observer: Rene Temmink (NED)
Anderlecht – Arsenal
Referee: Davide Massa (ITA)
Assistant Referee 1: Alberto Tegoni (ITA)
Assistant Referee 2: Gianmattia Tasso (ITA)
Fourth Official: Wesley Alen (BEL)
Referee Observer: Paul Allaerts (BEL)
Middlesborough – Dynamo Kyiv
Referee: Svein-Erik Edvartsen (NOR)
Assistant Referee 1:Magnus Lundberg (NOR)
Assistant Referee 2: Jan Erik Engan (NOR)
Fourth Official: David Webb (ENG)
Referee Observer: Peter Jones (ENG)
10 February 2016
Salzburg – AS Roma
Referee: Radu Petrescu (ROU)
Assistant Referee 1: Adrian Ghinguleac (ROU)
Assistant Referee 2: George Neacşu (ROU)
Fourth Official: Sebastian Gishamer (AUT)
Referee Observer: Stefan Messner (AUT)
Midtjylland – Atlético Madrid
Referee Jonathan Lardot (BEL)
Assistant Referee 1: Laurent Conotte (BEL)
Assistant Referee 2: Frédéric Godelaine (BEL)
Fourth Official: Morten Krogh (DEN)
Referee Observer: Jan Carlsen (DEN)
Príbram – CSKA Moskva
Referee: Ivaylo Stoyanov (BUL)
Assistant Referee 1: Ivo Kolev (BUL)
Assistant Referee 2: Georgi Doynov (BUL)
Fourth Official: Vojtěch Severýn (CZE)
Referee Observer: Vaclav Krondl (CZE)
Celtic – Valencia
Referee: Craig Pawson (ENG)
Assistant Referee 1: Adam Nunn (ENG)
Assistant Referee 2: Edward Smart (ENG)
Fourth Official: Donald Robertson (SCO)
Referee Observer: John Fleming (SCO)
Elfsborg – Real Madrid
Referee: Kristo Tohver (EST)
Assistant Referee 1: Aron Härsing (EST)
Assistant Referee 2: Dmitri Vinogradov (EST)
Fourth Official: Per Melin (SWE)
Referee Observer: Leif Sundell (SWE)