2 February 2016River Plate – Universidad de Chile
Referee: Patricio Loustau (ARG, photo)
Assistant Referee 1: Gustavo Rossi (ARG)
Assistant Referee 2: Lucas Germanotta (ARG)
Fourth Official: Silvio Trucco (ARG)
Referee Observer: Martin Vazquez (URU)
Huracan – Caracas
Referee: Patricio Polic (CHI)
Assistant Referee 1: Carlos Astroza (CHI)
Assistant Referee 2: Christian Schiemann (CHI)
Fourth Official: Claudio Puga (CHI)
Referee Observer: Luis Pasturenzi (ARG)
3 February 2016
Cesar Vallejo – Sao Paulo
Referee: Roddy Zambrano (ECU)
Assistant Referee 1: Luis Vera (ECU)
Assistant Referee 2: Juan Macias (ECU)
Fourth Official: Vinicio Espinel (ECU)
Referee Observer: Antonio Arnao (PER)
Puebla – Racing
Referee: Daniel Fedorczuk (URU)
Assistant Referee 1: Miguel Nievas (URU)
Assistant Referee 2: Carlos Pastorino (URU)
Fourth Official: Jonathan Fuentes (URU)
Referee Observer: Gilberto Alcala (MEX)
4 February 2016
Independiente del Valle – Guarani
Referee: Juan Soto (VEN)
Assistant Referee 1: Jorge Urrego (VEN)
Assistant Referee 2: Carlos Lopez (VEN)
Fourth Official: Marlon Escalante (VEN)
Referee Observer: Miguel Erazo (ECU)
Oriente Petrolero – Santa Fe
Referee: Pericles Cortez (BRA)
Assistant Referee 1: Kleber Gil (BRA)
Assistant Referee 2: Rodrigo Correa (BRA)
Fourth Official: Dewson Freitas (BRA)
Referee Observer: Hebert Aguilera (BOL)