16 February 2016
River Plate – Palmeiras
Referee: Julio Bascunan (CHI, photo)
Assistant Referee 1: Francisco Mondria (CHI)
Assistant Referee 2: Marcelo Barraza (CHI)
Fourth Official: Eduardo Gamboa (CHI)
Referee Observer: Juan Cardellino (URU)
Deportivo Tachira – Olimpia
Referee: Heber Lopes (BRA)
Assistant Referee 1: Marcelo van Gasse (BRA)
Assistant Referee 2: Fabricio Vilarinho (BRA)
Fourth Official: Anderson Daronco (BRA)
Referee Observer: Candelario Andaracia (VEN)
Santa Fe – Cerro Porteno
Referee: Roberto García (MEX)
Assistant Referee 1: Jose Camargo (MEX)
Assistant Referee 2: Alberto Morin (MEX)
Fourth Official: Jorge Rojas (MEX)
Referee Observer: Denver Perdomo (COL)
17 February 2016
Sao Paulo – The Strongest
Referee: Mario Diaz De Vivar (PAR)
Assistant Referee 1: Carlos Caceres (PAR)
Assistant Referee 2: Milciades Saldivar (PAR)
Fourth Official: Jose Mendez (PAR)
Referee Observer: Ednilson Corona (BRA)
Melgar – Atletico Mineiro
Referee: Wilson Lamouroux (COL)
Assistant Referee 1: Wilmar Navarro (COL)
Assistant Referee 2: Alexander Leon (COL)
Fourth Official: Gustavo Murillo (COL)
Referee Observer: Víctor Rivera (PER)
Cobreal – Corinthians
Referee: Andres Cunha (URU)
Assistant Referee 1: Mauricio Espinosa (URU)
Assistant Referee 2: Gabriel Popovits (URU)
Fourth Official: Oscar Rojas (URU)
Referee Observer: Guido Aros (CHI)
Toluca – Gremio
Referee: Gery Vargas (BOL)
Assistant Referee 1: Javier Bustillos (BOL)
Assistant Referee 2: Juan Montano (BOL)
Fourth Official: Alejandro Mancilla (BOL)
Referee Observer: Edgardo Codesal (MEX)
18 February 2016
Independiente Del Valle – Colo Colo
Referee: Jose Argote (VEN)
Assistant Referee 1: Luis Murillo (VEN)
Assistant Referee 2: Elbis Gomez (VEN)
Fourth Official: Jose Hoyos (VEN)
Referee Observer: Miguel Erazo (ECU)
Sporting Cristal – Penarol
Referee: Wilton Sampaio (BRA)
Assistant Referee 1: Emerson De Carvalho (BRA)
Assistant Referee 2: Alessandro Rocha (BRA)
Fourth Official: Leandro Vuaden (BRA)
Referee Observer: Cesar Mongrut (PER)
Pumas Unam – Emelec
Referee: Diego Haro (PER)
Assistant Referee 1: Jonny Bossio (PER)
Assistant Referee 2: Víctor Raez (PER)
Fourth Official: Miguel Santivanez (PER)
Referee Observer: Jorge Gasso (MEX)