Copa Sudamericana 2011 – Quarter-finals (First Leg)

1 November 2011
Independiente Santa Fe – Velez Sarsfield

Referee: Wilson Seneme (BRA, photo)
Assistant Referee 1: Roberto Braatz (BRA)
Assistant Referee 2: Emerson Carvalho (BRA)
Fourth Official: Marcelo Henrique (BRA)

2 November 2011
Universitario – Vasco da Gama
Referee: Carlos Vera (ECU)
Assistant Referee 1: Christian Lescano (ECU)
Assistant Referee 2: Carlos Herrera (ECU)
Fourth Official: Daniel Salazar (ECU)

3 November 2011
Arsenal – Universidad de Chile
Referee: Liber Prudente (URU)
Assistant Referee 1: Pablo Fandino (URU)
Assistant Referee 2: Carlos Pastorino (URU)
Fourth Official: Hector Martinez (URU)

Liga de Quito – Libertad
Referee: Sergio Pezzotta (ARG)
Assistant Referee 1: Ricardo Casas (ARG)
Assistant Referee 2: Hernan Maidana (ARG)
Fourth Official: Gabriel Favale (ARG)