Santos Laguna – Real Espana
Referee: Walter Quesada (CRC, photo)
Assistant Referee 1: Leonel Leal (CRC)
Assistant Referee 2: Octavio Jara (CRC)
Fourth Official: Jeffery Solis (CRC)
LA Galaxy – Motagua
Referee: Enrico Wijngaarde (SUR)
Assistant Referee 1: Ramon Louisville (SUR)
Assistant Referee 2: Garnet Page (JAM)
Fourth Official: Kevin Thomas (JAM)
Alajuelense – Morelia
Referee: Roberto Moreno (PAN)
Assistant Referee 1: Daniel Williamson (PAN)
Assistant Referee 2: Rey Mendoza (PAN)
Fourth Official: Jafeth Perea (PAN)
Seattle Sounders – Comunicaciones
Referee: Paul Delgadillo (MEX)
Assistant Referee 1: Marco Quinteros (MEX)
Assistant Referee 2: Salvador Rodriguez (MEX)
Cuarto: Alfredo Penaloza (MEX)
17 August 2011
Herediano – Monterrey
Referee: Marlon Mejia (SLV)
Assistant Referee 1: Miguel Mendez (SLV)
Assistant Referee 2: Douglas Bermudez (SLV)
Fourth Official: Joel Aguilar (SLV)
Pumas UNAM – FC Dallas
Referee: Jose Molina (HON)
Assistant Referee 1: Juan Rodas (HON)
Assistant Referee 2: Oscar Velasquez (HON)
Fourth Official: Hector Rodriguez (HON)
Colorado Rapids – Metapan
Referee: Trevor Taylor (BRB)
Assistant Referee 1: Adrian Goddard (BRB)
Assistant Referee 2: Clifton Garnes (BRB)
Fourth Official: Adrian Skeete (BRB)
18 August 2011
Tauro – Toronto FC
Referee: Marcos Brea (CUB)
Assistant Referee 1: Hiran Dopico (CUB)
Assistant Referee 2: Jose Rodriguez (CUB)
Fourth Official: David Rubalcaba (CUB)