Bolivia – Argentina
Referee: Esteban Ostojich (URU)
Assistant Referee 1: Carlos Barreiro (URU)
Assistant Referee 2: Andres Nievas (URU)
Fourth Official: Christian Ferreyra (URU)
VAR: Andres Cunha (URU)
AVAR: Antonio Garcia (URU)
Referee Assessor: Joel Ruiz (PAR)
Ecuador – Uruguay
Referee: Wilton Sampaio (BRA)
Assistant Referee 1: Danilo Manis (BRA)
Assistant Referee 2: Rafael Alves (BRA)
Fourth Official: Bruno Arleu (BRA)
VAR: Daniel Nobre (BRA)
AVAR: Igor Benevenuto (BRA)
Referee Assessor: Jose Buitrago (COL)
Venezuela – Paraguay
Referee: Andres Rojas (COL)
Assistant Referee 1: Dionisio Ruiz (COL)
Assistant Referee 2: Sebastian Vela (COL)
Fourth Official: John Hinestroza (COL)
VAR: Yadir Acuna (COL)
AVAR: David Rodriguez (COL)
Referee Assessor: Patricio Loustau (ARG)
Peru – Brazil
Referee: Fernando Rapallini (ARG)
Assistant Referee 1: Diego Bonfa (ARG)
Assistant Referee 2: Facundo Rodriguez (ARG)
Fourth Official: Pablo Echavarria (ARG)
VAR: German Delfino (ARG)
AVAR: Silvio Trucco (ARG)
Referee Assessor: Jairo Romero (VEN)
Chile – Colombia
Referee: Jesus Valenzuela (VEN)
Assistant Referee 1: Jorge Urrego (VEN)
Assistant Referee 2: Tulio Moreno (VEN)
Fourth Official: Angel Arteaga (VEN)
VAR: Juan Soto (VEN)
AVAR: Carlos Lopez (VEN)
Referee Assessor: Dario Ubriaco (URU)