Hajduk Split – Qabala IK
Referee: David Šmajc (SVN, photo)
Assistant Referee 1: David Gabrovec (SVN)
Assistant Referee 2: Tomaž Černe (SVN)
Fourth Official: Ante Terzić (CRO)
Referee Observer: Draženko Kovačić (CRO)
14 September 2022
KRC Genk – Slavia Praha
Referee: Jasmin Sabotic (LUX)
Assistant Referee 1: Joaquim Gomes (LUX)
Assistant Referee 2: Rafael Morim (LUX)
Fourth Official: Simon Bourdeaud’hui (BEL)
Referee Observer: Edgar Steinborn (GER)
MTK Budapest – FS Jelgava
Referee: Daniiar Sahi (KAZ)
Assistant Referee 1: Dmitrii Belogradov (KAZ)
Assistant Referee 2: Ilashbek Orynbaev (KAZ)
Fourth Official: Péter Zierkelbach (HUN)
Referee Observer: Ferenc Szwkely (HUN)
AFK Csikszereda – Galatasaray
Referee: Miloš Gigović (BIH)
Assistant Referee 1: Damir Lazić (BIH)
Assistant Referee 2: Enes Djozić (BIH)
Fourth Official: Lucian Rușandu (ROU)
Referee Observer: Igor Șațchii (MDA)
Rukh Lviv – Zaglebie Lubin
Referee: Miloš Savović (MNE)
Assistant Referee 1: Aleksandar Djikanović (MNE)
Assistant Referee 2: Marko Gojković (MNE)
Fourth Official: Sebastian Tarnowski (POL)
Referee Observer: Hannes Kaasik (EST)
Panathinaikos – Slavia Sofia
Referee: Snir Levi (ISR)
Assistant Referee 1: Tuval Koltunoff (ISR)
Assistant Referee 2: Daniel Ben-Hur (ISR)
Fourth Official: Alexandros Dragatis (GRE)
Referee Observer: Fritz Stuchlik (AUT)
BSC Young Boys – NK Domžale
Referee: Stefanos Koumbarakis (GRE)
Assistant Referee 1: Andreas Meindanas (GRE)
Assistant Referee 2: Chasan Koula (GRE)
Fourth Official: Sven Wolfensberger (SUI)
Referee Observer: Sascha Amhof (SUI)
AZ Alkmaar – Shamrock Rovers
Referee: Denys Shurman (UKR)
Assistant Referee 1: Volodymyr Vysotskyy (UKR)
Assistant Referee 2: Ihor Rybchenko (UKR)
Fourth Official: Erwin Blank (NED)
Referee Observer: Rien Koopman (NED)
Žalgiris Vilnius – AS Trenčin
Referee: Ion Orlic (MDA)
Assistant Referee 1: Vadim Vicol (MDA)
Assistant Referee 2: Natalia Ceban (MDA)
Fourth Official: Vilius Paulauskas (LTU)
Referee Observer: Sergejus Slyva (LTU)
SC Ashdod – Borac Banja Luka
Referee: Oleksiy Derevinskyy (UKR)
Assistant Referee 1: Oleksandr Berkut (UKR)
Assistant Referee 2: Oleksiy Myronov (UKR)
Fourth Official: Aviad Shiloach (ISR)
Referee Observer: Leontios Trattou (CYP)
Crvena Zvezda – Omonia Limassol
Referee: Luca Cibelli (SUI)
Assistant Referee 1: Vital Jobin (SUI)
Assistant Referee 2: Matthias Sbrissa (SUI)
Fourth Official: Predrag Janjuš (SRB)
Referee Observer: Zoran Petrović (SRB)
FC Nantes – FC Pyunik
Referee: Robert Jenkins (WAL)
Assistant Referee 1: Jordan Christopher (WAL)
Assistant Referee 2: Connor Thomas (WAL)
Fourth Official: Hakim Salem (FRA)
Referee Observer: Stephen Tanner (ENG)
AIK – Union Lëtzebuerg
Referee: Viktor Kopiyevskyy (UKR,)
Assistant Referee 1: Vitaliy Skoblya (UKR)
Assistant Referee 2: Yuriy Fedorak (UKR)
Fourth Official: Erik Mattsson (SWE)
Referee Observer: Petteri Kari (FIN)
Molde – Hibernian
Referee: Kaarlo Hämäläinen (FIN)
Assistant Referee 1: Sami Nykänen (FIN)
Assistant Referee 2: Veli-Matti Leppänen (FIN)
Fourth Official: Mathias Stofringshaug (NOR)
Referee Observer: Kjell Alseth (NOR)
15 September 2022
Astana – Apolonia
Referee: Martin Dohal (SVK)
Assistant Referee 1: Milan Štrbo (SVK)
Assistant Referee 2: Jakub Košecky (SVK)
Fourth Official: Nikita Ytrobin (KAZ)
Referee Observer: Orhan Erdemir (TUR)
Referee: David Šmajc (SVN, photo)
Assistant Referee 1: David Gabrovec (SVN)
Assistant Referee 2: Tomaž Černe (SVN)
Fourth Official: Ante Terzić (CRO)
Referee Observer: Draženko Kovačić (CRO)
14 September 2022
KRC Genk – Slavia Praha
Referee: Jasmin Sabotic (LUX)
Assistant Referee 1: Joaquim Gomes (LUX)
Assistant Referee 2: Rafael Morim (LUX)
Fourth Official: Simon Bourdeaud’hui (BEL)
Referee Observer: Edgar Steinborn (GER)
MTK Budapest – FS Jelgava
Referee: Daniiar Sahi (KAZ)
Assistant Referee 1: Dmitrii Belogradov (KAZ)
Assistant Referee 2: Ilashbek Orynbaev (KAZ)
Fourth Official: Péter Zierkelbach (HUN)
Referee Observer: Ferenc Szwkely (HUN)
AFK Csikszereda – Galatasaray
Referee: Miloš Gigović (BIH)
Assistant Referee 1: Damir Lazić (BIH)
Assistant Referee 2: Enes Djozić (BIH)
Fourth Official: Lucian Rușandu (ROU)
Referee Observer: Igor Șațchii (MDA)
Rukh Lviv – Zaglebie Lubin
Referee: Miloš Savović (MNE)
Assistant Referee 1: Aleksandar Djikanović (MNE)
Assistant Referee 2: Marko Gojković (MNE)
Fourth Official: Sebastian Tarnowski (POL)
Referee Observer: Hannes Kaasik (EST)
Panathinaikos – Slavia Sofia
Referee: Snir Levi (ISR)
Assistant Referee 1: Tuval Koltunoff (ISR)
Assistant Referee 2: Daniel Ben-Hur (ISR)
Fourth Official: Alexandros Dragatis (GRE)
Referee Observer: Fritz Stuchlik (AUT)
BSC Young Boys – NK Domžale
Referee: Stefanos Koumbarakis (GRE)
Assistant Referee 1: Andreas Meindanas (GRE)
Assistant Referee 2: Chasan Koula (GRE)
Fourth Official: Sven Wolfensberger (SUI)
Referee Observer: Sascha Amhof (SUI)
AZ Alkmaar – Shamrock Rovers
Referee: Denys Shurman (UKR)
Assistant Referee 1: Volodymyr Vysotskyy (UKR)
Assistant Referee 2: Ihor Rybchenko (UKR)
Fourth Official: Erwin Blank (NED)
Referee Observer: Rien Koopman (NED)
Žalgiris Vilnius – AS Trenčin
Referee: Ion Orlic (MDA)
Assistant Referee 1: Vadim Vicol (MDA)
Assistant Referee 2: Natalia Ceban (MDA)
Fourth Official: Vilius Paulauskas (LTU)
Referee Observer: Sergejus Slyva (LTU)
SC Ashdod – Borac Banja Luka
Referee: Oleksiy Derevinskyy (UKR)
Assistant Referee 1: Oleksandr Berkut (UKR)
Assistant Referee 2: Oleksiy Myronov (UKR)
Fourth Official: Aviad Shiloach (ISR)
Referee Observer: Leontios Trattou (CYP)
Crvena Zvezda – Omonia Limassol
Referee: Luca Cibelli (SUI)
Assistant Referee 1: Vital Jobin (SUI)
Assistant Referee 2: Matthias Sbrissa (SUI)
Fourth Official: Predrag Janjuš (SRB)
Referee Observer: Zoran Petrović (SRB)
FC Nantes – FC Pyunik
Referee: Robert Jenkins (WAL)
Assistant Referee 1: Jordan Christopher (WAL)
Assistant Referee 2: Connor Thomas (WAL)
Fourth Official: Hakim Salem (FRA)
Referee Observer: Stephen Tanner (ENG)
AIK – Union Lëtzebuerg
Referee: Viktor Kopiyevskyy (UKR,)
Assistant Referee 1: Vitaliy Skoblya (UKR)
Assistant Referee 2: Yuriy Fedorak (UKR)
Fourth Official: Erik Mattsson (SWE)
Referee Observer: Petteri Kari (FIN)
Molde – Hibernian
Referee: Kaarlo Hämäläinen (FIN)
Assistant Referee 1: Sami Nykänen (FIN)
Assistant Referee 2: Veli-Matti Leppänen (FIN)
Fourth Official: Mathias Stofringshaug (NOR)
Referee Observer: Kjell Alseth (NOR)
15 September 2022
Astana – Apolonia
Referee: Martin Dohal (SVK)
Assistant Referee 1: Milan Štrbo (SVK)
Assistant Referee 2: Jakub Košecky (SVK)
Fourth Official: Nikita Ytrobin (KAZ)
Referee Observer: Orhan Erdemir (TUR)