Real Betis – Eintracht Frankfurt
Referee: Marco Guida (ITA, photo)
Assistant Referee 1: Ciro Carbone (ITA)
Assistant Referee 2: Giorgio Peretti (ITA)
Fourth Official: Fabio Maresca (ITA)
VAR: Massimiliano Irrati (ITA)
AVAR: Marco Di Bello (ITA)
Referee Observer: Jorn-West Larsen (DEN)
Referee: Marco Guida (ITA, photo)
Assistant Referee 1: Ciro Carbone (ITA)
Assistant Referee 2: Giorgio Peretti (ITA)
Fourth Official: Fabio Maresca (ITA)
VAR: Massimiliano Irrati (ITA)
AVAR: Marco Di Bello (ITA)
Referee Observer: Jorn-West Larsen (DEN)
FC Porto – Olympique Lyonnais
Referee: Jose Sanchez Martinez (ESP)
Assistant Referee 1: Raul Cabanero Martinez (ESP)
Assistant Referee 2: Inigo Prieto Lopez (ESP)
Fourth Official: Cesar Soto Grado (ESP)
VAR: Alejandro Hernandez Hernandez (ESP)
AVAR: Jose Munuera Montero (ESP)
Referee Observer: Michael Riley (ENG)
10 March 2022
Sevilla FC – West Ham United
Referee: Sandro Schärer (SUI)
Assistant Referee 1: Stephane de Almeida (SUI)
Assistant Referee 2: Jonas Erni (SUI)
Fourth Official: Lukas Fähndrich (SUI)
VAR: Sascha Stegemann (GER)
AVAR: Bastian Dankert (GER)
Referee Observer: Vlado Svilokos (CRO)
Rangers FC – Crvena Zvezda
Referee: Serdar Gözübüyük (NED)
Assistant Referee 1: Joost van Zuilen (NED)
Assistant Referee 2: Johan Balder (NED)
Fourth Official: Sander Van Der Eijk (NED)
VAR: Jochem Kamphuis (NED)
AVAR: Dennis Higler (NED)
Referee Observer: Costas Kapitanis (CYP)
SC Braga – AS Monaco
Referee: Felix Zwayer (GER)
Assistant Referee 1: Stefan Lupp (GER)
Assistant Referee 2: Marco Achmüller (GER)
Fourth Official: Sven Jablonski (GER)
VAR: Christian Dingert (GER)
AVAR: Harm Osmers (GER)
Referee Observer: William Young (SCO)
Atalanta BC – Bayer Leverkusen
Referee: Srdjan Jovanović (SRB)
Assistant Referee 1: Uroš Stojković (SRB)
Assistant Referee 2: Milan Mihajlović (SRB)
Fourth Official: Novak Simović (SRB)
VAR: Christopher Kavanagh (ENG)
AVAR: Stuart Attwell (ENG)
Referee Observer: Markus Nobs (SUI)
FC Barcelona – Galatasaray AS
Referee: Benoît Bastien (FRA)
Assistant Referee 1: Hicham Zakrani (FRA)
Assistant Referee 2: Aurelien Berthomieu (FRA)
Fourth Official: Jeremie Pignard (FRA)
VAR: Willy Delajod (FRA)
AVAR: Benoît Millot (FRA)
Referee Observer: Matteo Trefoloni (ITA)