West Region (16 October 2021)
Al Wadha – Al Nassr
Referee: Ma Ning (CHN, photo)
Assistant Referee 1: Cao Yi (CHN)
Assistant Referee 2: Shi Xiang (CHN)
Fourth Official: Ali Al Qaysi (IRQ)
VAR: Fu Ming (CHN)
Persepolis FC – Al Hilal
Referee: Ryuji Sato (JPN)
Assistant Referee 1: Hiroshi Yamauchi (JPN)
Assistant Referee 2: Jun Mihara (JPN)
Fourth Official: Hanna Hattab (SYR)
VAR: Hiroyuki Kimura (JPN)
East Region (17 October 2021)
Pohang Steelers – Nagoya Grampus
Referee: Alireza Faghani (IRN)
Assistant Referee 1: Mohammadreza Mansouri (IRN)
Assistant Referee 2: Mohammadreza Abolfazli (IRN)
Fourth Official: Saoud Al Adba (QAT)
VAR: Muhammad Bin Jahari (SIN)
Jeonbuk Motors – Ulsan Hyundai
Referee: Mohammed Abdulla (UAE)
Assistant Referee 1: Mohamed Al Hammadi (UAE)
Assistant Referee 2: Hasan Suqatari (UAE)
Fourth Official: Ahmed Al Kaf (OMA)
VAR: Ammar Al Jneibi (UAE)