Paraguay – Peru
Referee: Nestor Pitana (ARG, photo)
Assistant Referee 1: Martin Soppi (URU)
Assistant Referee 2: Carlos Barreiro (URU)
Fourth Official: Gustavo Tejera (URU)
VAR: Daniel Fedorczuk (URU)
AVAR: Andres Matonte (URU)
Argentina – Ecuador
Referee: Roberto Tobar (CHI)
Assistant Referee 1: Christian Schiemann (CHI)
Assistant Referee 2: Claudio Rios (CHI)
Fourth Official: Christian Ferreyra (URU)
VAR: Cristian Garay (CHI)
AVAR: Andres Cunha (URU)
Uruguay – Chile
Referee: Eber Aquino (PAR)
Assistant Referee 1: Eduardo Cardozo (PAR)
Assistant Referee 2: Milciades Saldivar (PAR)
Fourth Official: Arnaldo Samaniego (PAR)
VAR: Juan Benitez (PAR)
AVAR: Jose Mendez (PAR)
Colombia – Venezuela
Referee: Guillermo Guerrero (ECU)
Assistant Referee 1: Byron Romero (ECU)
Assistant Referee 2: Ricardo Baren (ECU)
Fourth Official: Augusto Aragon (ECU)
VAR: Carlos Orbe (ECU)
AVAR: Christian Lescano (ECU)
Brazil – Bolivia
Referee: Leodan Gonzalez (URU)
Assistant Referee 1: Nicolas Taran (URU)
Assistant Referee 2: Richard Trinidad (URU)
Fourth Official: Facundo Tello (ARG)
VAR: Esteban Ostojich (URU)
AVAR: Fernando Rapallini (ARG)