First Leg, 22 January 2018Montevideo Wanderers – Olimpia
Referee: Anderson Daronco (BRA, photo)
Assistant Referee 1: Rodrigo Correa (BRA)
Assistant Referee 2: Guilherme Camilo (BRA)
Fourth Official: Wagner Reway (BRA)
Referee Assessor: Jorge Jaimes (PER)
Deportivo Macara – Deportivo Tachira
Referee: Andrés Rojas (COL)
Assistant Referee 1: Alexander León (COL)
Assistant Referee 2: Wilmar Navarro (COL)
Fourth Official: Carlos Betancur (COL)
Referee Assessor: Juan Lugones (BOL)
Oriente Petrolero – Universitario
Referee: Carlos Orbe (ECU)
Assistant Referee 1: Byron Romero (ECU)
Assistant Referee 2: Luis Vera (ECU)
Fourth Official: Roberto Sánchez (ECU)
Referee Assessor: Claudio Puga (CHI)
Second Leg, 26 January 2018
Deportivo Tachira – Deportivo Macara
Referee: Michael Espinoza (PER)
Assistant Referee 1: Víctor Raez (PER)
Assistant Referee 2: Michael Orue (PER)
Fourth Official: Joel Alarcón (PER)
Referee Assessor: José Buitrago (COL)
Olimpia – Montevideo Wanderers
Referee: Fernando Rapallini (ARG)
Assistant Referee 1: Gabriel Chade (ARG)
Assistant Referee 2: Cristian Navarro (ARG)
Fourth Official: Fernando Echenique (ARG)
Referee Assessor: Nilson Monção (BRA)
Universitario – Oriente Petrolero
Referee: Esteban Ostojich (URU)
Assistant Referee 1: Miguel Nievas (URU)
Assistant Referee 2: Gabriel Popovits (URU)
Fourth Official: Jonathan Fuentes (URU)
Referee Assessor: Joel Ruiz (PAR)