Seattle – Tigres
Referee: Elmer Bonilla (SLV, photo)
Assistant Referee 1: Douglas Bermudez (SLV)
Assistant Referee 2: Hector Recinos (SLV)
Fourth Official: Ruben Medrano (SLV)
Monterrey – Xelaju
Referee: Marcos Brea (CUB)
Assistant Referee 1: Hiran Dopico (CUB)
Assistant Referee 2: Jose Rodriguez (CUB)
Fourth Official: David Rubalcaba (CUB)
13 March 2013
Santos Laguna – Houston Dynamo
Referee: Enrico Wijngaarde (SUR)
Assistant Referee 1: Ricardo Louisville (SUR)
Assistant Referee 2: Egbert Paesch (ARU)
Fourth Official: Rudolph Angela (ARU)
Los Angeles – Herediano
Referee: Walter Lopez (GUA)
Assistant Referee 1: Gerson Lopez (GUA)
Assistant Referee 2: Ronaldo De La Cruz (GUA)
Fourth Official: Oscar Reyna (GUA)