22 January 2013Referee: Heber Lopes (BRA, photo)
Assistant Referee 1: Altemir Hausmann (BRA)
Assistant Referee 2: Marcio Santiago (BRA)
Fourth Official: Francisco Chacon (MEX)
Referee Observer: Francisco Ramirez (MEX)
Tigre – Anzoategui
Referee: Carlos Amarilla (PAR)
Assistant Referee 1: Carlos Caceres (PAR)
Assistant Referee 2: Milciades Saldivar (PAR)
Fourth Official: Diego Ceballos (ARG)
Referee Observer: Carlos Coradina (ARG)
23 January 2013
LDU Quito – Gremio
Referee: Wilmar Roldan (COL)
Assistant Referee 1: Eduardo Diaz (COL)
Assistant Referee 2: Alexander Guzman (COL)
Fourth Official: Roddy Zambrano (ECU)
Referee Observer: Bomer Fierro (ECU)
Sao Paulo – Bolivar
Referee: Roberto Silvera (URU)
Assistant Referee 1: Mauricio Espinosa (URU)
Assistant Referee 2: Marcelo Costa (URU)
Fourth Official: Paulo Oliveira (BRA)
Referee Observer: Ednilson Corona (BRA)
24 January 2013
Deportes Tolima – Universidad Vallejo
Referee: Juan Soto (VEN)
Assistant Referee 1: Jorge Urrego (VEN)
Assistant Referee 2: Luis Sanchez (VEN)
Fourth Official: Imer Machado (COL)
Referee Observer: Oscar Ruiz (COL)
Defensor Sporting – Olimpia
Referee: Diego Abal (ARG)
Assistant Referee 1: Hernan Maidana (ARG)
Assistant Referee 2: Juan Belatti (ARG)
Fourth Official: Fernando Falce (URU)
Referee Observer: Ernesto Filippi (URU)