Millonarios – Palmeiras
Referee: Victor Carrillo (PER, photo)
Assistant Referee 1: Cesar Escano (PER)
Assistant Referee 2: Raul Lopez (PER)
Fourth Official: Henry Gambetta (PER)
Cerro Porteno – Colon
Referee: Dario Ubriaco (URU)
Assistant Referee 1: Miguel Nievas (URU)
Assistant Referee 2: Nicolas Taran (URU)
Fourth Official: Daniel Fedorczuk (URU)
24 October 2012
Atletico Goianiense – Universidad Catolica
Referee: Carlos Amarilla (PAR)
Assistant Referee 1: Milciades Saldivar (PAR)
Assistant Referee 2: Hugo Martinez (PAR)
Fourth Official: Ulises Mereles (PAR)
Sao Paulo – Liga de Loja
Referee: Julio Quintana (PAR)
Assistant Referee 1: Carlos Caceres (PAR)
Assistant Referee 2: Dario Gaona (PAR)
Fourth Official: Enrique Caceres (PAR)
Gremio – Barcelona
Referee: Patricio Loustau (ARG)
Assistant Referee 1: Diego Bonfa (ARG)
Assistant Referee 2: Juan Belatti (ARG)
Fourth Official: Federico Beligoy (ARG)
25 October 2012
Liverpool – Independiente
Referee: Carlos Vera (ECU)
Assistant Referee 1: Juan Cedeno (ECU)
Assistant Referee 2: Luis Alvarado (ECU)
Fourth Official: Roddy Zambrano (ECU)
Tigre – Deportivo Quito
Referee: Sandro Ricci (BRA)
Assistant Referee 1: Roberto Braatz (BRA)
Assistant Referee 2: Marcelo Van Gasse (BRA)
Fourth Official: Marcelo Henrique (BRA)
Emelec – Universidad de Chile
Referee: Saul Laverni (ARG)
Assistant Referee 1: Ernesto Uziga (ARG)
Assistant Referee 2: Ivan Nunez (ARG)
Fourth Official: German Delfino (ARG)