Olimpia – Emelec
Referee: Leandro Vuaden (BRA, photo)
Assistant Referee 1: Roberto Braatz (BRA)
Assistant Referee 2: Rodrigo Joia (BRA)
Fourth Official: Ulises Mereles (PAR)
Envigado – Liverpool
Referee: Juan Soto (VEN)
Assistant Referee 1: Jorge Urrego (VEN)
Assistant Referee 2: Rafael Yanez (VEN)
Fourth Official: Luis Sanchez (COL)
Cobreloa – Barcelona
Referee: Julio Quintana (PAR)
Assistant Referee 1: Nicolas Yegros (PAR)
Assistant Referee 2: Hugo Martinez (PAR)
Fourth Official: Claudio Puga (CHI)
29 August 2012
Liga de Loja – Nacional
Referee: Georges Buckley (PER)
Assistant Referee 1: Jorge Hurtado (PER)
Assistant Referee 2: Braulio Cornejo (PER)
Fourth Official: Daniel Salazar (ECU)
Independiente – Boca Juniors
Referee: Nestor Pitana (ARG)
Assistant Referee 1: Ricardo Casas (ARG)
Assistant Referee 2: Hernan Maidana (ARG)
Fourth Official: Patricio Loustau (ARG)
Mineros de Guyana – Cerro Porteno
Referee: Jose Buitrago (COL)
Assistant Referee 1: Wilmar Navarro (COL)
Assistant Referee 2: Rafael Rivas (COL)
Fourth Official: Mayker Gomez (VEN)
Universidad Catolica – Deportes Tolima
Referee: Liber Prudente (URU)
Assistant Referee 1: Marcelo Costa (URU)
Assistant Referee 2: Gabriel Popovits (URU)
Fourth Official: Jorge Osorio (CHI)
30 August 2012
Deportivo Quito – Aurora
Referee: Julio Bascunan (CHI)
Assistant Referee 1: Julio Diaz (CHI)
Assistant Referee 2: Sergio Roman (CHI)
Fourth Official: Diego Lara (ECU)
Tigre – Argentinos Juniors
Referee: German Delfino (ARG)
Assistant Referee 1: Gustavo Esquivel (ARG)
Assistant Referee 2: Ernesto Uziga (ARG)
Fourth Official: Saul Laverni (ARG)
Racing Club – Santa Fe
Referee: Sergio Pezzotta (ARG)
Assistant Referee 1: Diego Bonfa (ARG)
Assistant Referee 2: Juan Belatti (ARG)
Fourth Official: Diego Abal (ARG)
Guarani – Millonarios
Referee: Raul Orosco (BOL)
Assistant Referee 1: Efrain Castro (BOL)
Assistant Referee 2: Arol Valda (BOL)
Fourth Official: Antonio Arias (PAR)