8 May 2012Libertad – Cruz Azul
Assistant Referee 1: Emerson Carvalho (BRA)
Assistant Referee 2: Dibert Pedrosa (BRA)
Fourth Official: Ricardo Marques (BRA)
Velez Sarsfield – Atletico Nacional
Referee: Julio Quintana (PAR)
Assistant Referee 1: Rodney Aquino (PAR)
Assistant Referee 2: Carlos Caceres (PAR)
Fourth Official: Ulises Mereles (PAR)
9 May 2012
Union Espanola – Boca Juniors
Referee: Wilmar Roldan (COL)
Assistant Referee 1: Humberto Clavijo (COL)
Assistant Referee 2: Eduardo Diaz (COL)
Fourth Official: Adrian Velez (COL)
Lanus – Vasco da Gama
Referee: Carlos Amarilla (PAR)
Assistant Referee 1: Dario Gaona (PAR)
Assistant Referee 2: Hugo Martinez (PAR)
Fourth Official: Enrique Caceres (PAR)
Corinthians – Emelec
Referee: Dario Ubriaco (URU)
Assistant Referee 1: Miguel Nievas (URU)
Assistant Referee 2: Marcelo Costa (URU)
Fourth Official: Daniel Fedorczuk (URU)
10 May 2012
Santos – Bolivar
Referee: Martin Vazquez (URU)
Assistant Referee 1: Carlos Pastorino (URU)
Assistant Referee 2: Carlos Changala (URU)
Fourth Official: Hector Martinez (URU)
Universidad de Chile – Deportivo Quito
Referee: Nestor Pitana (ARG)
Assistant Referee 1: Hernan Maidana (ARG)
Assistant Referee 2: Diego Bonfa (ARG)
Fourth Official: Patricio Loustau (ARG)
Fluminense – Internacional
Referee: Wilson Seneme (BRA)
Assistant Referee 1: Carlos Berkenbrock (BRA)
Assistant Referee 2: Marcelo Van Gasse (BRA)
Fourth Official: Evandro Roman (BRA)