Bolivar – Santos
Referee: Enrique Osses (CHI, photo)
Assistant Referee 1: Francisco Mondria (CHI)
Assistant Referee 2: Carlos Astroza (CHI)
Fourth Official: Claudio Puga (CHI)
Internacional – Fluminense
Referee: Paulo Oliveira (BRA)
Assistant Referee 1: Alessandro Rocha (BRA)
Assistant Referee 2: Emerson Carvalho (BRA)
Fourth Official: Ricardo Marques (BRA)
1 May 2012
Atletico Nacional – Velez Sarsfield
Referee: Dario Ubriaco (URU)
Assistant Referee 1: Miguel Nievas (URU)
Assistant Referee 2: Marcelo Costa (URU)
Fourth Official: Hector Martinez (URU)
Cruz Azul – Libertad
Referee: Sergio Pezzotta (ARG)
Assistant Referee 1: Ricardo Casas (ARG)
Assistant Referee 2: Juan Belatti (ARG)
Fourth Official: German Delfino (ARG)
2 May 2012
Boca Juniors – Union Espanola
Referee: Victor Carrillo (PER)
Assistant Referee 1: Jonny Bossio (PER)
Assistant Referee 2: Cesar Escano (PER)
Fourth Official: Henry Gambetta (PER)
Emelec – Corinthians
Referee: Jose Buitrago (COL)
Assistant Referee 1: Abraham Gonzalez (COL)
Assistant Referee 2: Wilson Berio (COL)
Fourth Official: Imer Machado (COL)
Vasco da Gama – Lanus
Referee: Roberto Silvera (URU)
Assistant Referee 1: Mauricio Espinosa (URU)
Assistant Referee 2: Carlos Pastorino (URU)
Fourth Official: Liber Prudente (URU)
3 May 2012
Deportivo Quito – Universidad de Chile
Referee: Francisco Chacon (MEX)
Assistant Referee 1: Salvador Rodriguez (MEX)
Assistant Referee 2: Victor Calderon (MEX)
Fourth Official: Jorge Gasso (MEX)