20 September 2011Referee: Terry Vaughn (USA, photo)
Assistant Referee 1: Chris Strickland (USA)
Assistant Referee 2: Eric Boria (USA)
Fourth Official: Baldomero Toledo (USA)
Monterrey – Comunicaciones
Referee: Jair Marrufo (USA)
Assistant Referee 1: Charles Morgante (USA)
Assistant Referee 2: Corey Rockwell (USA)
Fourth Official: Edvin Jurisevic (USA)
Seattle Sounders – Herediano
Referee: Neil Brizan (TRI)
Assistant Referee 1: Dion Neil (TRI)
Assistant Referee 2: Ainsley Rochard (TRI)
Fourth Official: Lee Davis (TRI)
21 September 2011
FC Dallas – Pumas Unam
Referee: Walter Lopez (GUA)
Assistant Referee 1: Gerson Lopez (GUA)
Assistant Referee 2: Ronaldo De la Cruz (GUA)
Fourth Official: Otto Barrios (GUA)
Colorado Rapids – Real Espana
Referee: Enrico Wijngaarde (SUR)
Assistant Referee 1: Ricardo Louisville (SUR)
Assistant Referee 2: Egberth Paesch (ARU)
Fourth Official: Rudolph Angela (ARU)
Alajuelense – LA Galaxy
Referee: Courtney Campbell (JAM)
Assistant Referee 1: Keble Williams (JAM)
Assistant Referee 2: Lloyd Reader (JAM)
Fourth Official: Valdin Legister (JAM)
22 September 2011
Santos Laguna – Metapan
Referee: David Gantar (CAN)
Assistant Referee 1: Darren Clark (CAN)
Assistant Referee 2: Daniel Belleau (CAN)
Fourth Official: Silviu Petrescu (CAN)
Motagua – Morelia
Referee: Javier Santos (PUR)
Assistant Referee 1: Antonio Lopez (PUR)
Assistant Referee 2: Keytzell Corrales (NCA)
Fourth Official: Franklin Jarquin (NCA)