29 October 2017Shakhtsior Salihorsk – FC Nitra
Referee: Jørgen Daugbjerg Burchardt (DEN, photo)
Assistant Referee 1: Jesper Dahl (DEN)
Assistant Referee 2: Jakob Mastrup (DEN)
Fourth Official: Anton Lashuk (BLR)
Referee Observer: Aleh Chykun (BLR)
31 October 2017
Lokomotiva Zagreb – Željezničar
Referee: Oleksandr Derdo (UKR)
Assistant Referee 1: Ihor Alokhin (UKR)
Assistant Referee 2: Oleksandr Zhukov (UKR)
Fourth Official: Ivan Vučković (CRO)
Referee Observer: Igor Pristovnik (CRO)
Legia Warszawa – Ajax
Referee: Horațiu Feșnic (ROU)
Assistant Referee 1: Alexandru Cerei (ROU)
Assistant Referee 2: Valentin Avram (ROU)
Fourth Official: Zbigniew Dobrynin (POL)
Referee Observer: Robert Małek (POL)
1 November 2017
Internazionale Milano – Esbjerg
Referee: Mario Zebec (CRO)
Assistant Referee 1: Borut Križarić (CRO)
Assistant Referee 2: Jerko Crnčić (CRO)
Fourth Official: Daniele Minelli (ITA)
Referee Observer: Francesco Bianchi (SUI)
FC Krasnodar – Budapest Honvéd
Referee: Suren Baliyan (ARM)
Assistant Referee 1: Mesrop Ghazaryan (ARM)
Assistant Referee 2: Atom Sevgulyan (ARM)
Fourth Official: Artem Chistyakov (RUS)
Referee Observer: Aleksandr Gvardis (RUS)
Zimbru Chișinău – Molde FK
Referee: Sándor Andó-Szabó (HUN)
Assistant Referee 1: Balázs Szert (HUN)
Assistant Referee 2: Balázs Szalai (HUN)
Fourth Official: Ion Orlic (MDA)
Referee Observer: Igor Șațchi (MDA)
Sparta Praha – Red Bull Salzburg
Referee: Bojan Nikolić (SRB)
Assistant Referee 1: Nikola Djorović (SRB)
Assistant Referee 2: Miloje Milićević (SRB)
Fourth Official: Ondřej Berka (CZE)
Referee Observer: Karel Bohuněk (CZE)
FK Brodarac – FC Saburtalo
Referee: Luca Barbeno (SMR)
Assistant Referee 1: Marco Ercolani (SMR)
Assistant Referee 2: Laurentiu Ilie (SMR)
Fourth Official: Andrija Stojanović (SRB)
Referee Observer: Zoran Petrović (SRB)